Maria Paz Gonzalez-Perez
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Explore the profile of Maria Paz Gonzalez-Perez including associated specialties, affiliations and a list of published articles.
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14
Citations
208
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Recent Articles
1.
Rose R, Gonzalez-Perez M, Nolan D, Ganta K, LaFleur T, Cross S, et al.
Microbiol Spectr
. 2022 Sep;
10(5):e0250822.
PMID: 36173332
HIV-1 sequence population structure among brain and nonbrain cellular compartments is incompletely understood. Here, we compared proviral and high-quality consensus single-molecule real-time (SMRT) sequences derived from CD3 T cells and...
2.
Rose R, Gonzalez-Perez M, Nolan D, Cross S, Lamers S, Luzuriaga K
J Virol
. 2021 Sep;
95(23):e0120221.
PMID: 34495695
Understanding tissue-based HIV-1 proviral population structure is important for improving treatment strategies for individuals with HIV-associated neurological disorders (HAND). Previous analyses have revealed HIV-1 envelope () population structure between brain...
3.
Lamers S, Fogel G, Nolan D, Barbier A, Rose R, Singer E, et al.
AIDS Res Hum Retroviruses
. 2019 Feb;
35(6):588-596.
PMID: 30793919
The HIV envelope protein contains five hypervariable domains (V1-V5) that are fundamental for cell entry. We contrasted modifications in the variable domains derived from a panel of 24 tissues from...
4.
Quitadamo B, Peters P, Koch M, Luzuriaga K, Cheng-Mayer C, Clapham P, et al.
Arch Virol
. 2018 Nov;
164(2):473-482.
PMID: 30415390
Macrophage (mac)-tropic human immnunodeficiency virus type 1 (HIV-1) and simian immnunodeficiency virus (SIV) in brain are associated with neurological disease. Mac-tropic HIV-1 evolves enhanced CD4 interactions that enable macrophage infection...
5.
Brese R, Gonzalez-Perez M, Koch M, OConnell O, Luzuriaga K, Somasundaran M, et al.
J Neurovirol
. 2018 Apr;
24(4):439-453.
PMID: 29687407
Despite combined antiretroviral therapy (cART), HIV+ patients still develop neurological disorders, which may be due to persistent HIV infection and selective evolution in brain tissues. Single-molecule real-time (SMRT) sequencing technology...
6.
Quitadamo B, Peters P, Repik A, OConnell O, Mou Z, Koch M, et al.
J Virol
. 2017 Nov;
92(2).
PMID: 29118121
HIV-1 R5 variants exploit CCR5 as a coreceptor to infect both T cells and macrophages. R5 viruses that are transmitted or derived from immune tissue and peripheral blood are mainly...
7.
Gonzalez-Perez M, Peters P, OConnell O, Silva N, Harbison C, Cummings Macri S, et al.
J Virol
. 2017 Aug;
91(20).
PMID: 28768859
Untreated HIV-positive (HIV-1) individuals frequently suffer from HIV-associated neurocognitive disorders (HAND), with about 30% of AIDS patients suffering severe HIV-associated dementias (HADs). Antiretroviral therapy has greatly reduced the incidence of...
8.
Peters P, Gonzalez-Perez M, Musich T, Moore Simas T, Lin R, Morse A, et al.
Retrovirology
. 2015 Jun;
12:48.
PMID: 26055104
Background: HIV-1 variants carrying non-macrophage-tropic HIV-1 R5 envelopes (Envs) are predominantly transmitted and persist in immune tissue even in AIDS patients who have highly macrophage-tropic variants in the brain. Non-macrophage-tropic...
9.
Musich T, OConnell O, Gonzalez-Perez M, Derdeyn C, Peters P, Clapham P
Retrovirology
. 2015 Mar;
12:25.
PMID: 25809903
Background: Non-mac-tropic HIV-1 R5 viruses are predominantly transmitted and persist in immune tissue even in AIDS patients who carry highly mac-tropic variants in the brain. Non-mac-tropic R5 envelopes (Envs) require...
10.
OConnell O, Repik A, Reeves J, Gonzalez-Perez M, Quitadamo B, Anton E, et al.
J Virol
. 2012 Oct;
87(1):187-98.
PMID: 23055568
HIV-1 R5 viruses vary extensively in their capacity to infect macrophages. R5 viruses that confer efficient infection of macrophages are able to exploit low levels of CD4 for infection and...