Maria P Lopez-Alberca

No abstract available.

The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, is involved in signal transduction downstream of multiple growth factor, cytokine and integrin receptors. Its requirement for complete RAS-MAPK...

Alkynyl aziridines can be obtained from the catalytic asymmetric aziridination (AZ reaction) of alkynyl imines with diazo compounds in high yields and high asymmetric inductions mediated by a chiral boroxinate...

Serine hydrolases are one of the largest and most diverse enzyme classes in Nature. Most serine hydrolases lack selective inhibitors, which are valuable probes for assigning functions to these enzymes....

The synthesis, isolation, and complete characterization (NMR and X-Ray diffraction techniques) of stable mononuclear (palladium and platinum) alkoxy-biscarbene complexes is reported. These compounds are easily accessible through stoichiometric transmetalation reactions...

The efficient copper oxidative homocoupling (CuCl/TMEDA/O2) of alkynyl Fischer carbene complexes yields bis-carbene complexes having pi-tethers. The bimetallic complexes are exceptional templates to prepare diverse organic symmetric structures connected by...

[reaction: see text] The Pd-catalyzed reaction of beta-arylaminochromium(0) carbene complexes produces by transmetalation the first isolated and X-ray structurally characterized bis-Pd(II) carbene complex, as well as other alternative reaction pathways,...