Maria Narozna
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Explore the profile of Maria Narozna including associated specialties, affiliations and a list of published articles.
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11
Citations
83
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Recent Articles
1.
Narozna M, Latham M, Gorbsky G
bioRxiv
. 2024 Dec;
PMID: 39677655
Cultured pluripotent stem cells are unique in being the only fully diploid immortal human cell lines. However, during continued culture, they acquire significant chromosome abnormalities. Chromosome 12 trisomy is the...
2.
Narozna M, Krajka-Kuzniak V, Bednarczyk-Cwynar B, Baer-Dubowska W
Molecules
. 2023 Aug;
28(15).
PMID: 37570726
HCC is a highly aggressive malignancy with limited treatment options. In this study, novel conjugates of non-steroidal anti-inflammatory drugs (NSAIDs)-Ibuprofen and Ketoprofen-with oleanolic acid oximes derivatives (OAO) were synthesized, and...
3.
Krajka-Kuzniak V, Papierska K, Narozna M, Jelinska A, Majchrzak-Celinska A
Molecules
. 2022 Dec;
27(24).
PMID: 36557911
Vulvar squamous cell carcinoma (VSCC) is a rare malignancy with a relatively good prognosis. However, the prognosis remains poor for elderly patients and those with a significant depth of tumor...
4.
Narozna M, Krajka-Kuzniak V, Kleszcz R, Baer-Dubowska W
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163154
Our earlier studies showed that coupling nonsteroidal anti-inflammatory drugs (NSAIDs) with oleanolic acid derivatives increased their anti-inflammatory activity in human hepatoma cells. The aim of this study was to evaluate...
5.
Narozna M, Rubis B
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445368
Recently, we have experienced a serious pandemic. Despite significant technological advances in molecular technologies, it is very challenging to slow down the infection spread. It appeared that due to globalization,...
6.
Baer-Dubowska W, Narozna M, Krajka-Kuzniak V
Molecules
. 2021 Aug;
26(16).
PMID: 34443544
Naturally occurring pentacyclic triterpenoid oleanolic acid (OA) serves as a good scaffold for additional modifications to achieve synthetic derivatives. Therefore, a large number of triterpenoids have been synthetically modified in...
7.
Narozna M, Krajka-Kuzniak V, Bednarczyk-Cwynar B, Kucinska M, Kleszcz R, Kujawski J, et al.
Pharmaceuticals (Basel)
. 2021 Aug;
14(7).
PMID: 34358114
Combining NSAIDs with conventional therapeutics was recently explored as a new strategy in cancer therapy. Our earlier studies showed that novel oleanolic acid oximes (OAO) conjugated with aspirin or indomethacin...
8.
Narozna M, Krajka-Kuzniak V, Bednarczyk-Cwynar B, Kleszcz R, Kujawski J, Baer-Dubowska W
Pharmaceuticals (Basel)
. 2021 Jan;
14(1).
PMID: 33396453
Nrf2 and NF-κB play a key role in inflammation-driven cancers. Conjugation of anti-inflammatory drugs with oleanolic acid oxime (OAO) may enhance their therapeutic potential as a result of downregulation of...
9.
Narozna M, Krajka-Kuzniak V, Kleszcz R, Bednarczyk-Cwynar B, Szaefer H, Baer-Dubowska W
Eur J Pharmacol
. 2020 Jul;
883:173307.
PMID: 32668287
Our previous study demonstrated that new oleanolic acid oxime (OAO) derivatives and their conjugates with aspirin (ASP) inhibit NF-κB activation. Evidence exists that the downregulation of NF-κB negatively interferes with...
10.
Krajka-Kuzniak V, Bednarczyk-Cwynar B, Paluszczak J, Szaefer H, Narozna M, Zaprutko L, et al.
Bioorg Chem
. 2019 Oct;
93:103326.
PMID: 31586705
The aim of this study was to evaluate the effect of new oleanolic acid oxime (OAO) derivatives and their conjugates with aspirin (ASP) on the expression and activation of NF-κB...