Maria Isabel Hernandez-Alvarez
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Explore the profile of Maria Isabel Hernandez-Alvarez including associated specialties, affiliations and a list of published articles.
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32
Citations
1699
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Recent Articles
11.
Soukupova J, Malfettone A, Bertran E, Hernandez-Alvarez M, Penuelas-Haro I, Dituri F, et al.
Int J Mol Sci
. 2021 Jun;
22(11).
PMID: 34073989
(1) Background: The transforming growth factor (TGF)-β plays a dual role in liver carcinogenesis. At early stages, it inhibits cell growth and induces apoptosis. However, TGF-β expression is high in...
12.
Hernandez-Alvarez M, Zorzano A
Cancers (Basel)
. 2021 Jun;
13(11).
PMID: 34073868
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer. Due to its rising incidence and limited therapeutic options, HCC has become a leading cause of cancer-related death worldwide, accounting...
13.
Cisa-Wieczorek S, Hernandez-Alvarez M
Cells
. 2020 Dec;
9(12).
PMID: 33291746
Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the natural biosynthesis and degradation...
14.
Testoni G, Olmeda B, Duran J, Lopez-Rodriguez E, Aguilera M, Hernandez-Alvarez M, et al.
Hum Mol Genet
. 2020 Nov;
29(21):3554-3565.
PMID: 33219378
The glycogenin knockout mouse is a model of Glycogen Storage Disease type XV. These animals show high perinatal mortality (90%) due to respiratory failure. The lungs of glycogenin-deficient embryos and...
15.
Lloberas J, Munoz J, Hernandez-Alvarez M, Cardona P, Zorzano A, Celada A
Autophagy
. 2020 Nov;
16(12):2307-2309.
PMID: 33171058
MFN2 (mitofusin 2) is required for mitochondrial fusion and for mitochondria-endoplasmic reticulum interaction. Using myeloid-conditional KO mice models, we found that MFN2 but not MFN1 is a prerequisite for the...
16.
Hernandez-Alvarez M, Sebastian D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, et al.
Cell
. 2019 May;
177(4):881-895.e17.
PMID: 31051106
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in...
17.
Ivanova S, Polajnar M, Narbona-Perez A, Hernandez-Alvarez M, Frager P, Slobodnyuk K, et al.
EMBO J
. 2019 Apr;
38(10).
PMID: 30979779
TP53INP2 positively regulates autophagy by binding to Atg8 proteins. Here, we uncover a novel role of TP53INP2 in death-receptor signaling. TP53INP2 sensitizes cells to apoptosis induced by death receptor ligands....
18.
Keiran N, Ceperuelo-Mallafre V, Calvo E, Hernandez-Alvarez M, Ejarque M, Nunez-Roa C, et al.
Nat Immunol
. 2019 Apr;
20(5):581-592.
PMID: 30962591
Succinate is a signaling metabolite sensed extracellularly by succinate receptor 1 (SUNCR1). The accumulation of succinate in macrophages is known to activate a pro-inflammatory program; however, the contribution of SUCNR1...
19.
Barbier-Torres L, Iruzubieta P, Fernandez-Ramos D, C Delgado T, Taibo D, Guitierrez-de-Juan V, et al.
Nat Commun
. 2017 Dec;
8(1):2068.
PMID: 29233977
Acetaminophen (APAP) is the active component of many medications used to treat pain and fever worldwide. Its overuse provokes liver injury and it is the second most common cause of...
20.
Zamudio-Vazquez R, Ivanova S, Moreno M, Hernandez-Alvarez M, Giralt E, Bidon-Chanal A, et al.
Chem Sci
. 2017 Nov;
6(8):4537-4549.
PMID: 29142702
The synthesis of a new small library of quinoxaline-containing peptides is described. After cytotoxic evaluation in four human cancer cell lines, as well as detailed biological studies, it was found...