Maria Angela Sortino
Overview
Explore the profile of Maria Angela Sortino including associated specialties, affiliations and a list of published articles.
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71
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1645
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Recent Articles
1.
Di Menna L, Alborghetti M, De Bartolo M, Borro M, Gentile G, Zinni M, et al.
NPJ Parkinsons Dis
. 2025 Jan;
11(1):9.
PMID: 39755677
Metabotropic glutamate (mGlu) receptors are candidate drug targets for therapeutic intervention in Parkinson's disease (PD). Here we focused on mGlu3, a receptor subtype involved in synaptic regulation and neuroinflammation. mGlu3...
2.
Barraco M, Kudova E, Bucolo C, Ciranna L, Sortino M, Chisari M
Neuropharmacology
. 2025 Jan;
266:110294.
PMID: 39755203
The central nervous system is a well-known steroidogenic tissue producing, among others, cholesterol metabolites such as neuroactive steroids, oxysterols and steroid hormones. It is well known that these endogenous molecules...
3.
Merlo S, Costa L, Chiechio S, Busceti C, Ciranna L, Santangelo R, et al.
J Alzheimers Dis
. 2023 Sep;
96(1):77-91.
PMID: 37742639
Background: The effects of Alzheimer's disease (AD) pathology on the experience of pain are poorly understood. Objective: To understand the pathophysiological mechanisms underlying pain sensory transmission in the transgenic mouse...
4.
Gullotta G, Costantino G, Sortino M, Spampinato S
Int J Mol Sci
. 2023 Jun;
24(11).
PMID: 37298096
Microglia are the resident immune cells of the central nervous system that guarantee immune surveillance and exert also a modulating role on neuronal synaptic development and function. Upon injury, microglia...
5.
Merlo S, Caruso G, Korde D, Khodorovska A, Humpel C, Sortino M
Biomolecules
. 2023 Feb;
13(2).
PMID: 36830742
Melatonin (MEL) is a neurohormone endowed with neuroprotective activity, exerted both directly on neuronal cells and indirectly through modulation of responsive glial cells. In particular, MEL's effects on microglia are...
6.
Chisari M, Barraco M, Bucolo C, Ciranna L, Sortino M
Eur J Pharmacol
. 2022 Nov;
938:175389.
PMID: 36435235
Microglia represent the resident immune system in the brain. They mediate neuroinflammatory processes and have been described as important regulators of homeostasis in the central nervous system (CNS). Among several...
7.
Spampinato S, Costantino G, Merlo S, Canonico P, Sortino M
Biomolecules
. 2022 Sep;
12(9).
PMID: 36139013
Microglia, together with astrocytes and pericytes, cooperate to ensure blood-brain barrier (BBB) stability, modulating endothelial responses to inflammatory insults. Agonists of the sphingosine 1 phosphate (S1P) receptors, such as siponimod...
8.
DAmico F, Costantino G, Salvatorelli L, Ramondetta A, De Pasquale R, Sortino M, et al.
Adv Med Sci
. 2022 Jul;
67(2):262-268.
PMID: 35839539
Purpose: Epidermal hyperplasia and the involvement of immune cells characterize the clinical picture of psoriasis. Among the several factors involved, attention has been focused on sirtuin 1 (SIRT1) - a...
9.
Merlo S, Caruso G, Bonfili L, Spampinato S, Costantino G, Eleuteri A, et al.
Biochem Pharmacol
. 2022 Jun;
202:115151.
PMID: 35750198
Microglial cells play a central but yet debated role in neuroinflammatory events occurring in Alzheimer's disease (AD). We here explored how microglial features are modulated by melatonin following β-amyloid (Aβ42)-induced...
10.
Spampinato S, Sortino M, Salomone S
Adv Pharmacol
. 2022 Jun;
94:95-139.
PMID: 35659378
Sphingosine-1-phosphate (S1P) is a lipid that binds and activates five distinct receptor subtypes, S1P, S1P, S1P, S1P, S1P, widely expressed in different cells, tissues and organs. In the cardiovascular system...