Margo A Brinton
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Explore the profile of Margo A Brinton including associated specialties, affiliations and a list of published articles.
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63
Citations
2019
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Recent Articles
1.
Siemer J, Le T, Paul A, Boykin D, Brinton M, Wilson W, et al.
ACS Infect Dis
. 2024 Dec;
11(1):88-94.
PMID: 39666861
Arthropod-borne members of the genus cause significant human disease. Four serotypes of dengue virus are endemic globally, and approximately 50 percent of the world's population lives in a dengue-affected area....
2.
Stauber C, Jacob-Nascimento L, Grosch C, Sousa M, Portilho M, Anjos R, et al.
Braz J Infect Dis
. 2024 Nov;
29(1):104484.
PMID: 39612524
Introduction: Dengue cases in the Americas in 2024 have reached record highs, especially in Brazil. However, surveillance remains suboptimal and new methods are needed to monitor Dengue Virus (DENV) spread....
3.
Terrell J, Le T, Paul A, Brinton M, Wilson W, Poon G, et al.
Nat Commun
. 2024 Jun;
15(1):5428.
PMID: 38926367
Potential G-quadruplex sites have been identified in the genomes of DNA and RNA viruses and proposed as regulatory elements. The genus Orthoflavivirus contains arthropod-transmitted, positive-sense, single-stranded RNA viruses that cause...
4.
Basu M, Zurla C, Auroni T, Vanover D, Chaves L, Sadhwani H, et al.
Nat Microbiol
. 2024 Jun;
9(8):2160-2172.
PMID: 38839984
Dengue is a major global health threat, and there are no approved antiviral agents. Prior research using Cas13 only demonstrated dengue mitigation in vitro. Here we demonstrate that systemic delivery...
5.
Muirhead A, Zhu K, Brown J, Basu M, Brinton M, Costa F, et al.
Environ Sci Technol Lett
. 2023 Jun;
7(9):659-664.
PMID: 37293193
Despite substantial advances in knowledge and understanding about Zika virus (ZIKV), limitations in surveillance for this mainly asymptomatic infection constrain attempts to characterize the epidemiological distribution of the virus. Monitoring...
6.
Zhu K, Hill C, Muirhead A, Basu M, Brown J, Brinton M, et al.
Water Res
. 2023 Jun;
241:120116.
PMID: 37270953
During the 2015-2016 Zika virus (ZIKV) epidemic in the Americas, serological cross-reactivity with other flaviviruses and relatively high costs of nucleic acid testing in the region hindered the capacity for...
7.
Cheng Y, Medina A, Yao Z, Basu M, Natekar J, Lang J, et al.
Cell Rep
. 2022 Jun;
39(9):110885.
PMID: 35649379
Physiological blood-tissue barriers play a critical role in separating the circulation from immune-privileged sites and denying access to blood-borne viruses. The mechanism of virus restriction by these barriers is poorly...
8.
Cui D, Espinola E, Arora K, Brinton M
J Virol
. 2021 Sep;
95(22):e0104021.
PMID: 34495694
We previously identified a subset of interferon-stimulated genes (ISGs) upregulated by West Nile virus (WNV) infection in wild-type mouse embryo fibroblasts (MEFs) after viral proteins had inhibited type I interferon...
9.
Brinton M, Gulyaeva A, Balasuriya U, Dunowska M, Faaberg K, Goldberg T, et al.
J Gen Virol
. 2021 Aug;
102(8).
PMID: 34356005
The family comprises enveloped RNA viruses with a linear, positive-sense genome of approximately 12.7 to 15.7 kb. The spherical, pleomorphic virions have a median diameter of 50-74 nm and include...
10.
Blanchard E, Vanover D, Bawage S, Tiwari P, Rotolo L, Beyersdorf J, et al.
Nat Biotechnol
. 2021 Feb;
39(6):717-726.
PMID: 33536629
Cas13a has been used to target RNA viruses in cell culture, but efficacy has not been demonstrated in animal models. In this study, we used messenger RNA (mRNA)-encoded Cas13a for...