Margaryta Babych
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Explore the profile of Margaryta Babych including associated specialties, affiliations and a list of published articles.
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11
Citations
48
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Recent Articles
1.
Babych M, Garelja M, Nguyen P, Hay D, Bourgault S
J Am Chem Soc
. 2024 Sep;
146(37):25513-25526.
PMID: 39225636
The islet amyloid polypeptide (IAPP), also known as amylin, is a hormone playing key physiological roles. However, its aggregation and deposition in the pancreatic islets are associated with type 2...
2.
Kihal N, Archambault M, Babych M, Nazemi A, Bourgault S
Soft Matter
. 2024 Sep;
20(39):7821-7831.
PMID: 39225438
Amyloid fibrils are proteinaceous nanostructures known for their ability to activate the innate immune system, which has been recently exploited for their use as self-adjuvanted antigen delivery systems for vaccines....
3.
Sebastiao M, Babych M, Quittot N, Kumar K, Arnold A, Marcotte I, et al.
Biochim Biophys Acta Biomembr
. 2023 Jan;
1865(3):184118.
PMID: 36621762
Numerous pathophysiological conditions are associated with the misfolding and aggregation of proteins into insoluble amyloid fibrils. The mechanisms by which this process leads to cellular dysfunction remain elusive, though several...
4.
Fortier M, Cote-Cyr M, Nguyen V, Babych M, Nguyen P, Gaudreault R, et al.
Front Mol Biosci
. 2022 Oct;
9:1017336.
PMID: 36262476
The islet amyloid polypeptide (IAPP) is a 37-residue aggregation-prone peptide hormone whose deposition as insoluble fibrils in the islets of Langerhans is associated with type II diabetes. Therapeutic interventions targeting...
5.
Babych M, Nguyen P, Cote-Cyr M, Kihal N, Quittot N, Golizeh M, et al.
Biochemistry
. 2021 Jul;
60(29):2285-2299.
PMID: 34264642
The accumulation of insoluble amyloids in the pancreatic islets is a pathological hallmark of type II diabetes and correlates closely with the loss of β-cell mass. The predominant component of...
6.
Quittot N, Fortier M, Babych M, Nguyen P, Sebastiao M, Bourgault S
FASEB J
. 2021 Jan;
35(2):e21306.
PMID: 33475205
Glycosaminoglycans (GAGs) are long and unbranched anionic heteropolysaccharides that have been associated with virtually all amyloid deposits. Soluble sulfated GAGs are known for their propensity to promote the self-assembly of...
7.
Al-Halifa S, Zottig X, Babych M, Cote-Cyr M, Bourgault S, Archambault D
Nanomaterials (Basel)
. 2020 Oct;
10(10).
PMID: 33036404
Protein fibrils characterized with a cross-β-sheet quaternary structure have gained interest as nanomaterials in biomedicine, including in the design of subunit vaccines. Recent studies have shown that by conjugating an...
8.
Gauthier L, Babych M, Segura M, Bourgault S, Archambault D
Immunobiology
. 2020 Aug;
225(4):151962.
PMID: 32747018
By modulating specific immune responses against antigens, adjuvants are used in many vaccine preparations to enhance protective immunity. The C-terminal domain of the protein P97 (P97c) of Mycoplasma hyopneumoniae, which...
9.
Priemel T, Palia R, Babych M, Thibodeaux C, Bourgault S, Harrington M
Proc Natl Acad Sci U S A
. 2020 Mar;
117(14):7613-7621.
PMID: 32209666
Inspired largely by the role of the posttranslationally modified amino acid dopa (DOPA) in mussel adhesion, catechol functional groups have become commonplace in medical adhesives, tissue scaffolds, and advanced smart...
10.
Zottig X, Al-Halifa S, Babych M, Quittot N, Archambault D, Bourgault S
Small
. 2019 Jul;
15(33):e1901806.
PMID: 31268238
Peptides that self-assemble into cross-β-sheet amyloid structures constitute promising building blocks to construct highly ordered proteinaceous materials and nanoparticles. Nevertheless, the intrinsic polymorphism of amyloids and the difficulty of controlling...