Margaret E McCormick
Overview
Explore the profile of Margaret E McCormick including associated specialties, affiliations and a list of published articles.
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17
Citations
808
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Recent Articles
1.
Benavides N, Spessott W, Sanmillan M, Vargas M, Livingston M, Erickson N, et al.
Front Immunol
. 2020 Nov;
11():545414.
PMID: 33162974
Neonatal hemophagocytic lymphohistiocytosis (HLH) is a medical emergency that can be associated with significant morbidity and mortality. Often these patients present with familial HLH (f-HLH), which is caused by gene...
2.
Spessott W, Sanmillan M, Kulkarni V, McCormick M, Giraudo C
Traffic
. 2017 May;
18(7):442-452.
PMID: 28471021
Adaptive and innate immunity utilize the perforin-killing pathway to eliminate virus-infected or cancer cells. Cytotoxic T-lymphocytes (CTLs) and natural killer cells mediate this process by releasing toxic proteins at the...
3.
Spessott W, Sanmillan M, McCormick M, Kulkarni V, Giraudo C
Proc Natl Acad Sci U S A
. 2017 Mar;
114(11):E2176-E2185.
PMID: 28265073
The atypical lipid-anchored Syntaxin 11 (STX11) and its binding partner, the Sec/Munc (SM) protein Munc18-2, facilitate cytolytic granule release by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Patients...
4.
McCormick M, Manduchi E, Witschey W, Gorman R, Gorman 3rd J, Jiang Y, et al.
J Biomech
. 2016 Dec;
50:11-19.
PMID: 27916240
Despite substantial evidence for the central role of hemodynamic shear stress in the functional integrity of vascular endothelial cells, hemodynamic and molecular regulation of the endocardial endothelium lining the heart...
5.
McCormick M, Manduchi E, Witschey W, Gorman R, Gorman 3rd J, Jiang Y, et al.
J Am Heart Assoc
. 2016 Apr;
5(4):e003170.
PMID: 27091183
Background: Unlike arteries, in which regionally distinct hemodynamics are associated with phenotypic heterogeneity, the relationships between endocardial endothelial cell phenotype and intraventricular flow remain largely unexplored. We investigated regional differences...
6.
McCormick M, Tzima E
Curr Opin Hematol
. 2016 Feb;
23(3):235-42.
PMID: 26906028
Purpose Of Review: Endothelial cells line the surface of the cardiovascular system and display a large degree of heterogeneity due to developmental origin and location. Despite this heterogeneity, all endothelial...
7.
McCormick M, Collins C, Makarewich C, Chen Z, Rojas M, Willis M, et al.
J Am Heart Assoc
. 2015 Jan;
4(1):e001210.
PMID: 25600142
Background: Dilated cardiomyopathy is characterized by impaired contractility of cardiomyocytes, ventricular chamber dilatation, and systolic dysfunction. Although mutations in genes expressed in the cardiomyocyte are the best described causes of...
8.
Spessott W, Sanmillan M, McCormick M, Patel N, Villanueva J, Zhang K, et al.
Blood
. 2015 Jan;
125(10):1566-77.
PMID: 25564401
Familial hemophagocytic lymphohistiocytosis (F-HLH) and Griscelli syndrome type 2 (GS) are life-threatening immunodeficiencies characterized by impaired cytotoxic T lymphocyte (CTL) and natural killer (NK) cell lytic activity. In the majority...
9.
McCormick M, Rojas M, Moser-Katz T, Tzima E, Reader J
PLoS One
. 2014 Oct;
9(10):e109325.
PMID: 25296172
A naturally-occurring fragment of tyrosyl-tRNA synthetase (TyrRS) has been shown in higher eukaryotes to 'moonlight' as a pro-angiogenic cytokine in addition to its primary role in protein translation. Pro-angiogenic cytokines...
10.
Jiang Y, Jimenez J, Ou K, McCormick M, Zhang L, Davies P
Circ Res
. 2014 Apr;
115(1):32-43.
PMID: 24755985
Rationale: Hemodynamic disturbed flow (DF) is associated with susceptibility to atherosclerosis. Endothelial Kruppel-Like Factor 4 (KLF4) is an important anti-inflammatory atheroprotective transcription factor that is suppressed in regions of DF....