Marek A Budzynski
Overview
Explore the profile of Marek A Budzynski including associated specialties, affiliations and a list of published articles.
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9
Citations
163
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Recent Articles
1.
Budzynski M, Wong A, Faghihi A, Teves S
Biochem Soc Trans
. 2024 Mar;
52(2):821-830.
PMID: 38526206
Mitosis involves intricate steps, such as DNA condensation, nuclear membrane disassembly, and phosphorylation cascades that temporarily halt gene transcription. Despite this disruption, daughter cells remarkably retain the parent cell's gene...
2.
Heat shock transcription factors demonstrate a distinct mode of interaction with mitotic chromosomes
Price R, Budzynski M, Shen J, Mitchell J, Kwan J, Teves S
Nucleic Acids Res
. 2023 Apr;
51(10):5040-5055.
PMID: 37114996
A large number of transcription factors have been shown to bind and interact with mitotic chromosomes, which may promote the efficient reactivation of transcriptional programs following cell division. Although the...
3.
Kwan J, Nguyen T, Uzozie A, Budzynski M, Cui J, Lee J, et al.
Elife
. 2023 Mar;
12.
PMID: 36995326
Transcription by RNA Polymerase II (Pol II) is initiated by the hierarchical assembly of the pre-initiation complex onto promoter DNA. Decades of research have shown that the TATA-box binding protein...
4.
Budzynski M, Teves S
Trends Biochem Sci
. 2022 Mar;
47(7):556-557.
PMID: 35307259
Topoisomerase 1 (Top1) relieves torsional stress on DNA, including from RNA Polymerase II (Pol II) transcription. A new study by Wiegard et al. uncovers an unexpected role of Top1 in...
5.
Price R, Budzynski M, Kundra S, Teves S
Genome
. 2020 Oct;
64(4):449-466.
PMID: 33113335
At the heart of the transcription process is the specific interaction between transcription factors (TFs) and their target DNA sequences. Decades of molecular biology research have led to unprecedented insights...
6.
Baker-Williams A, Hashmi F, Budzynski M, Woodford M, Gleicher S, Himanen S, et al.
Cell Rep
. 2019 Aug;
28(7):1894-1906.e6.
PMID: 31412254
The extracellular molecular chaperone heat shock protein 90 (eHSP90) stabilizes protease client the matrix metalloproteinase 2 (MMP2), leading to tumor cell invasion. Although co-chaperones are critical modulators of intracellular HSP90:client...
7.
Kijima T, Prince T, Tigue M, Yim K, Schwartz H, Beebe K, et al.
Sci Rep
. 2018 May;
8(1):6976.
PMID: 29725069
Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program. HSF1 is thought to be regulated by molecular chaperones, including...
8.
Budzynski M, Crul T, Himanen S, Toth N, Otvos F, Sistonen L, et al.
Cell Stress Chaperones
. 2017 May;
22(5):717-728.
PMID: 28474205
Defects in cellular protein homeostasis are associated with many severe and prevalent pathological conditions such as neurodegenerative diseases, muscle dystrophies, and metabolic disorders. One way to counteract these defects is...
9.
Budzynski M, Puustinen M, Joutsen J, Sistonen L
Mol Cell Biol
. 2015 May;
35(14):2530-40.
PMID: 25963659
In mammals the stress-inducible expression of genes encoding heat shock proteins is under the control of the heat shock transcription factor 1 (HSF1). Activation of HSF1 is a multistep process,...