Marcin Dobaczewski
Overview
Explore the profile of Marcin Dobaczewski including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
2747
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0
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Recent Articles
1.
Tissue transglutaminase induction in the pressure-overloaded myocardium regulates matrix remodelling
Shinde A, Dobaczewski M, de Haan J, Saxena A, Lee K, Xia Y, et al.
Cardiovasc Res
. 2017 Apr;
113(8):892-905.
PMID: 28371893
Aims: Tissue transglutaminase (tTG) is induced in injured and remodelling tissues, and modulates cellular phenotype, while contributing to matrix cross-linking. Our study tested the hypothesis that tTG may be expressed...
2.
Biernacka A, Cavalera M, Wang J, Russo I, Shinde A, Kong P, et al.
Circ Heart Fail
. 2015 May;
8(4):788-98.
PMID: 25985794
Background: Heart failure in diabetics is associated with cardiac hypertrophy, fibrosis and diastolic dysfunction. Activation of transforming growth factor-β/Smad3 signaling in the diabetic myocardium may mediate fibrosis and diastolic heart...
3.
Saxena A, Dobaczewski M, Rai V, Haque Z, Chen W, Li N, et al.
Am J Physiol Heart Circ Physiol
. 2014 Aug;
307(8):H1233-42.
PMID: 25128167
Regulatory T cells (Tregs) play a pivotal role in suppressing immune responses regulating behavior and gene expression in effector T cells, macrophages, and dendritic cells. Tregs infiltrate the infarcted myocardium;...
4.
Saxena A, Bujak M, Frunza O, Dobaczewski M, Gonzalez-Quesada C, Lu B, et al.
Cardiovasc Res
. 2014 Jun;
103(2):217-27.
PMID: 24891401
Aims: The CXC chemokine CXCL10 is up-regulated in the infarcted myocardium and limits cardiac fibrosis by inhibiting growth factor-mediated fibroblast migration. CXCL10 signals by binding to its receptor CXCR3; however,...
5.
Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, et al.
Circ Res
. 2013 Oct;
113(12):1331-44.
PMID: 24081879
Rationale: Diabetes mellitus is associated with cardiac fibrosis. Matricellular proteins are induced in fibrotic conditions and modulate fibrogenic and angiogenic responses by regulating growth factor signaling. Objective: Our aim was...
6.
Christia P, Bujak M, Gonzalez-Quesada C, Chen W, Dobaczewski M, Reddy A, et al.
J Histochem Cytochem
. 2013 May;
61(8):555-70.
PMID: 23714783
Mouse models of myocardial infarction are essential tools for the study of cardiac injury, repair, and remodeling. Our current investigation establishes a systematic approach for quantitative evaluation of the inflammatory...
7.
Chen W, Saxena A, Li N, Sun J, Gupta A, Lee D, et al.
Arterioscler Thromb Vasc Biol
. 2012 Sep;
32(11):2598-608.
PMID: 22995519
Objective: Effective postinfarction repair requires timely suppression of innate immune signals to prevent the catastrophic consequences of uncontrolled inflammation on cardiac geometry and function. In macrophages, interleukin-1 receptor-associated kinase (IRAK)-M...
8.
Dobaczewski M, de Haan J, Frangogiannis N
J Cardiovasc Transl Res
. 2012 Sep;
5(6):837-47.
PMID: 22956156
Cardiac fibroblasts are key cellular effectors of cardiac repair; their phenotype and function are modulated by interactions with extracellular matrix proteins. This review manuscript discusses the effects of the extracellular...
9.
Xia Y, Dobaczewski M, Gonzalez-Quesada C, Chen W, Biernacka A, Li N, et al.
Hypertension
. 2011 Sep;
58(5):902-11.
PMID: 21947471
The matricellular protein thrombospondin (TSP) 1 is induced after tissue injury and may regulate reparative responses by activating transforming growth factor-β, by suppressing angiogenesis and by modulating inflammation and matrix...
10.
Biernacka A, Dobaczewski M, Frangogiannis N
Growth Factors
. 2011 Jul;
29(5):196-202.
PMID: 21740331
Transforming growth factor β (TGF-β) is a central mediator of fibrogenesis. TGF-β is upregulated and activated in fibrotic diseases and modulates fibroblast phenotype and function, inducing myofibroblast transdifferentiation while promoting...