Marc Lopez-Cano
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Explore the profile of Marc Lopez-Cano including associated specialties, affiliations and a list of published articles.
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25
Citations
292
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Recent Articles
1.
Lopez-Cano M, Scortichini M, Tosh D, Salmaso V, Ko T, Salort G, et al.
J Am Chem Soc
. 2024 Dec;
147(1):874-879.
PMID: 39680577
Incorporating photoisomerizable moieties within drugs offers the possibility of rapid and reversible light-dependent switching between active and inactive configurations. Here, we developed a photoswitchable adenosine A receptor (AR) agonist that...
2.
Argerich J, Garma L, Lopez-Cano M, Alvarez-Montoya P, Gomez-Acero L, Fernandez-Duenas V, et al.
NPJ Parkinsons Dis
. 2024 Sep;
10(1):172.
PMID: 39256360
The orphan G protein-coupled receptor 37 (GPR37), widely associated with Parkinson's disease (PD), undergoes proteolytic processing under physiological conditions. The N-terminus domain is proteolyzed by a disintegrin and metalloproteinase 10...
3.
Taura J, Lopez-Cano M, Fernandez-Duenas V, Ciruela F
Curr Protoc
. 2023 Jun;
3(6):e794.
PMID: 37289022
G protein-coupled receptors (GPCRs) constitute the largest family of plasma membrane receptors and the main drug targets in therapeutics. GPCRs can establish direct receptor-receptor interactions (oligomerization), which can also be...
4.
Romero-Fernandez W, Taura J, Crans R, Lopez-Cano M, Fores-Pons R, Narvaez M, et al.
Mol Neurobiol
. 2022 Jul;
59(10):5955-5969.
PMID: 35829830
The adenosine A receptor (AR), dopamine D receptor (DR) and metabotropic glutamate receptor type 5 (mGluR) form AR-DR-mGluR heteroreceptor complexes in living cells and in rat striatal neurons. In the...
5.
Lopez-Cano M, Fernandez-Duenas V, Llebaria A, Ciruela F
Bio Protoc
. 2021 Oct;
7(23):e2628.
PMID: 34595296
Pain research is mostly based on experimental assays that use animal models, which may allow deciphering the physiopathology of this condition and to propel drug discovery. The formalin nociception test...
6.
Hull K, Fernandez-Duenas V, Schonberger M, Lopez-Cano M, Trauner D, Ciruela F
Bioconjug Chem
. 2021 Aug;
32(9):1979-1983.
PMID: 34448572
Adenosine receptors (ARs) play many important roles in physiology and have been recognized as potential targets for pain relief. Here, we introduce three photoswitchable adenosine derivatives that function as light-dependent...
7.
Lopez-Cano M, Font J, Aso E, Sahlholm K, Cabre G, Giraldo J, et al.
Br J Pharmacol
. 2021 Aug;
180(7):958-974.
PMID: 34363210
Background And Purpose: Opioid-based drugs are the gold standard medicines for pain relief. However, tolerance and several side effects (i.e. constipation and dependence) may occur upon chronic opioid administration. Photopharmacology...
8.
Lopez-Cano M, Filgaira I, Nolen E, Cabre G, Hernando J, Tosh D, et al.
Pharmacol Res
. 2021 Jun;
170:105731.
PMID: 34157422
Psoriasis is a chronic and relapsing inflammatory skin disease lacking a cure that affects approximately 2% of the population. Defective keratinocyte proliferation and differentiation, and aberrant immune responses are major...
9.
Valle-Leon M, Callado L, Aso E, Cajiao-Manrique M, Sahlholm K, Lopez-Cano M, et al.
Neuropsychopharmacology
. 2020 Oct;
46(3):665-672.
PMID: 33010795
According to the adenosine hypothesis of schizophrenia, the classically associated hyperdopaminergic state may be secondary to a loss of function of the adenosinergic system. Such a hypoadenosinergic state might either...
10.
Lopez-Cano M, Fernandez-Duenas V, Ciruela F
Methods Mol Biol
. 2019 Aug;
2040:41-50.
PMID: 31432474
Proximity ligation assay (PLA) is an antibody-based method that permits studying protein-protein interactions with high specificity and sensitivity. In brief, when a pair of specific antibodies is in close proximity,...