Marc A Seelen
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Explore the profile of Marc A Seelen including associated specialties, affiliations and a list of published articles.
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56
Citations
1124
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Recent Articles
1.
Faria B, Gaya DA Costa M, Meter-Arkema A, Berger S, Lima C, Pego C, et al.
Perit Dial Int
. 2023 Oct;
44(1):37-47.
PMID: 37794761
Background: Despite several advantages compared to haemodialysis (HD), peritoneal dialysis (PD) remains an underused dialysis technique due to its high technique failure rate related to membrane fibrosis and peritonitis events....
2.
Poppelaars F, Eskandari S, Damman J, Seelen M, Faria B, Gaya DA Costa M
Kidney Res Clin Pract
. 2023 Jun;
42(3):389-402.
PMID: 37313613
Background: Despite current matching efforts to identify optimal donor-recipient pairs for kidney transplantation, alloimmunity remains a major source of late transplant failure. Additional genetic parameters in donor-recipient matching could help...
3.
Tiller G, Lammerts R, Karijosemito J, Alkaff F, Diepstra A, Pol R, et al.
Front Immunol
. 2022 May;
13:845301.
PMID: 35493506
Background: The role of the complement system in antibody-mediated rejection (ABMR) is insufficiently understood. We aimed to investigate the role of local and systemic complement activation in active (aABMR). We...
4.
Poppelaars F, Gaya DA Costa M, Faria B, Eskandari S, Seelen M, Damman J
J Inflamm Res
. 2022 Apr;
15:2243-2254.
PMID: 35411171
Introduction: Kidney transplantation has excellent short-term results with current immunosuppression regimes, but long-term outcomes have barely improved over the past two decades. Hence, there is a need for new therapeutic...
5.
Poppelaars F, Gaya DA Costa M, Faria B, Eskandari S, Damman J, Seelen M
Clin Kidney J
. 2022 Feb;
15(2):278-286.
PMID: 35145642
Background: Improvement of long-term outcomes in kidney transplantation remains one of the most pressing challenges, yet drug development is stagnating. Human genetics offers an opportunity for much-needed target validation in...
6.
Poppelaars F, Gaya DA Costa M, Eskandari S, Damman J, Seelen M
Sci Rep
. 2021 Aug;
11(1):16483.
PMID: 34389747
Rejection after kidney transplantation remains an important cause of allograft failure that markedly impacts morbidity. Cytokines are a major player in rejection, and we, therefore, explored the impact of interleukin-6...
7.
Lammerts R, Lagendijk L, Tiller G, Dam W, Lancaster H, Daha M, et al.
Am J Physiol Renal Physiol
. 2021 Mar;
320(5):F947-F962.
PMID: 33719571
Renal endothelial cells (ECs) play crucial roles in vasorelaxation, ultrafiltration, and selective transport of electrolytes and water, but also in leakage of the glomerular filtration barrier and inflammatory processes like...
8.
Faria B, Gaya DA Costa M, Lima C, Willems L, Brandwijk R, Berger S, et al.
J Nephrol
. 2020 Dec;
34(3):801-810.
PMID: 33306183
Introduction: Various studies have reported the importance of complement regulators in preventing mesothelial damage during peritoneal dialysis (PD). Its assessment, however, is limited in clinical practice due to the lack...
9.
van Zanden J, Jager N, Seelen M, Daha M, Veldhuis Z, Leuvenink H, et al.
Am J Transplant
. 2020 Aug;
21(3):993-1002.
PMID: 32743873
In brain-dead donors immunological activation occurs, which deteriorates donor lung quality. Whether the complement system is activated and which pathways are herein involved, remain unknown. We aimed to investigate whether...
10.
Faria B, Canao P, Cai Q, Henriques C, Matos A, Poppelaars F, et al.
Am J Kidney Dis
. 2020 May;
76(5):669-678.
PMID: 32439421
Rationale & Objective: Glomerular C4d (C4dG) as an indicator of the lectin pathway of complement activation in immunoglobulin A nephropathy (IgAN) has been associated with more severe kidney damage. Recent...