Manuela Lavorato
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Explore the profile of Manuela Lavorato including associated specialties, affiliations and a list of published articles.
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16
Citations
195
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Recent Articles
11.
Perni S, Lavorato M, Beam K
Proc Natl Acad Sci U S A
. 2017 Dec;
114(52):13822-13827.
PMID: 29229815
Skeletal muscle contraction is triggered by Ca release from the sarcoplasmic reticulum (SR) in response to plasma membrane (PM) excitation. In vertebrates, this depends on activation of the RyR1 Ca...
12.
Lavorato M, Iyer V, Dewight W, Cupo R, Debattisti V, Gomez L, et al.
Proc Natl Acad Sci U S A
. 2017 Jan;
114(5):E849-E858.
PMID: 28096415
Exchanges of matrix contents are essential to the maintenance of mitochondria. Cardiac mitochondrial exchange matrix content in two ways: by direct contact with neighboring mitochondria and over longer distances. The...
13.
Lavorato M, Gupta P, Hopkins P, Franzini-Armstrong C
Eur J Transl Myol
. 2017 Jan;
26(4):6105.
PMID: 28078069
We have compared the ultrastructure of skeletal muscle biopsies from patients that have survived a [Malignant Hyperthermia, MH] episode and siblings that test positive for MH susceptibility with those from...
14.
Linsley J, Hsu I, Groom L, Yarotskyy V, Lavorato M, Horstick E, et al.
Proc Natl Acad Sci U S A
. 2016 Dec;
114(2):E228-E236.
PMID: 28003463
Skeletal muscle contractions are initiated by an increase in Ca released during excitation-contraction (EC) coupling, and defects in EC coupling are associated with human myopathies. EC coupling requires communication between...
15.
Lavorato M, Huang T, Iyer V, Perni S, Meissner G, Franzini-Armstrong C
J Muscle Res Cell Motil
. 2015 Feb;
36(2):205-14.
PMID: 25694159
In cardiac muscle, calmodulin (CaM) regulates the activity of several membrane proteins involved in Ca(2+) homeostasis (CaV1.2; RyR2, SERCA2, PMCA). Three engineered amino acid substitutions in the CaM binding site...
16.
Lavorato M, Bernabo I, Crescente A, Denoel M, Tripepi S, Brunelli E
Arch Environ Contam Toxicol
. 2012 Oct;
64(2):253-62.
PMID: 23064781
Endosulfan is an organochlorine pesticide that was recently labeled as a persistent organic pollutant, but it is still widely employed, particularly in developing countries. The goal of this study is...