Manuela Braun
Overview
Explore the profile of Manuela Braun including associated specialties, affiliations and a list of published articles.
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10
Citations
100
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Recent Articles
1.
Braun M, Lange C, Schatz P, Long B, Stanta J, Gorovits B, et al.
Mol Ther Methods Clin Dev
. 2024 Mar;
32(1):101217.
PMID: 38496304
Recombinant adeno-associated virus (AAV) vectors are the leading delivery vehicle used for gene therapies. Anti-AAV antibodies (AAV Abs) can interact with the viral capsid component of an AAV-based gene therapy...
2.
Kavita U, Sun K, Braun M, Lembke W, Mody H, Kamerud J, et al.
AAPS J
. 2023 Jul;
25(5):78.
PMID: 37523051
Interest and efforts to use recombinant adeno-associated viruses (AAV) as gene therapy delivery tools to treat disease have grown exponentially. However, gaps in understanding of the pharmacokinetics/pharmacodynamics (PK/PD) and disposition...
3.
Lauren A, Braun M, Cazzin C, Colleti K, Cox C, Dietz L, et al.
Bioanalysis
. 2022 Sep;
14(16):1085-1093.
PMID: 36125042
In this manuscript, the European Bioanalysis Forum reports back on their discussions on practical and scientific considerations related to bioanalytical applications of quantitative polymerase chain reaction. This publication follows an...
4.
Yang T, Braun M, Lembke W, McBlane F, Kamerud J, DeWall S, et al.
Mol Ther Methods Clin Dev
. 2022 Sep;
26:471-494.
PMID: 36092368
Immunogenicity has imposed a challenge to efficacy and safety evaluation of adeno-associated virus (AAV) vector-based gene therapies. Mild to severe adverse events observed in clinical development have been implicated with...
5.
Lauren A, Braun M, Byrne P, Cazzin C, Colletti K, Cox C, et al.
Bioanalysis
. 2021 Oct;
13(23):1723-1729.
PMID: 34708666
Polymerase chain reaction (PCR) is widely used in various fields of laboratory testing, ranging from forensic, molecular biology, medical and diagnostic applications to a wide array of basic research purposes....
6.
Pillutla R, Gorovits B, Gleason C, Quiroz J, Christopher D, Braun M, et al.
Bioanalysis
. 2020 Jun;
12(12):823-834.
PMID: 32558588
Historically, ligand-binding assays for pharmacokinetic samples employed duplicate rather than singlet-based analysis. Herein, the Translational and absorption, distribution, metabolism and excretion (ADME) Sciences Leadership Group of the International Consortium for...
7.
Kiesgen S, Schroder A, Schwarz T, Czupalla O, Braun M, Gnoth M, et al.
Bioanalysis
. 2016 Nov;
8(24):2581-2593.
PMID: 27884079
Determination of concentration-time profiles in cynomolgus monkeys of a therapeutic monoclonal antibody against a soluble target revealed a substantial discrepancy between a generic anti-human IgG capture/detection and target bridging assay...
8.
Sommer A, Kopitz C, Schatz C, Nising C, Mahlert C, Lerchen H, et al.
Cancer Res
. 2016 Aug;
76(21):6331-6339.
PMID: 27543601
The fibroblast growth factor receptor FGFR2 is overexpressed in a variety of solid tumors, including breast, gastric, and ovarian tumors, where it offers a potential therapeutic target. In this study,...
9.
Nagy P, Bene L, Hyun W, Vereb G, Braun M, Antz C, et al.
Cytometry A
. 2005 Sep;
67(2):86-96.
PMID: 16163690
Background: The combination of fluorescence resonance energy transfer (FRET) and flow cytometry offers a statistically firm approach to study protein associations. Fusing green fluorescent protein (GFP) to a studied protein...
10.
Schwarz G, Boehncke W, Braun M, Schroter C, Burster T, Flad T, et al.
J Invest Dermatol
. 2002 Aug;
119(1):44-9.
PMID: 12164923
Keratinocytes are an integral component of the skin immune system and function as nonprofessional antigen-presenting cells in pathophysiologic conditions when they express major histocompatibility complex class II molecules, e.g., in...