Manolis Roulis
Overview
Explore the profile of Manolis Roulis including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
816
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0
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Recent Articles
1.
Ding C, Yang X, Liu H, Roulis M, Chen H, Chen Y, et al.
J Mol Cell Biol
. 2025 Jan;
PMID: 39762134
The development and homeostasis of intestinal epithelium are mediated by actively proliferating Lgr5+ stem cells, which possess a remarkable self-renewal and differentiation capacity. Recently, our study demonstrated that m6A methylation...
2.
Kaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, et al.
Cell
. 2023 Aug;
186(18):3793-3809.e26.
PMID: 37562401
Hepatocytes, the major metabolic hub of the body, execute functions that are human-specific, altered in human disease, and currently thought to be regulated through endocrine and cell-autonomous mechanisms. Here, we...
3.
Ding C, Xu H, Yu Z, Roulis M, Qu R, Zhou J, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(33):e2203318119.
PMID: 35939687
γδ T cells are an abundant T cell population at the mucosa and are important in providing immune surveillance as well as maintaining tissue homeostasis. However, despite γδ T cells'...
4.
Zhang T, Ding C, Chen H, Zhao J, Chen Z, Chen B, et al.
Sci Adv
. 2022 Mar;
8(12):eabl5723.
PMID: 35333576
Colonic mucosal barrier dysfunction is one of the major causes of inflammatory bowel disease (IBD). However, the mechanisms underlying mucosal barrier dysfunction are poorly understood. -methyladenosine (mA) mRNA modification is...
5.
Linderman G, Zhao J, Roulis M, Bielecki P, Flavell R, Nadler B, et al.
Nat Commun
. 2022 Jan;
13(1):192.
PMID: 35017482
A key challenge in analyzing single cell RNA-sequencing data is the large number of false zeros, where genes actually expressed in a given cell are incorrectly measured as unexpressed. We...
6.
Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, et al.
Nature
. 2021 Mar;
592(7855):606-610.
PMID: 33658717
Intestinal stromal cells are known to modulate the propagation and differentiation of intestinal stem cells. However, the precise cellular and molecular mechanisms by which this diverse stromal cell population maintains...
7.
Roulis M, Kaklamanos A, Schernthanner M, Bielecki P, Zhao J, Kaffe E, et al.
Nature
. 2020 Apr;
580(7804):524-529.
PMID: 32322056
The initiation of an intestinal tumour is a probabilistic process that depends on the competition between mutant and normal epithelial stem cells in crypts. Intestinal stem cells are closely associated...
8.
Jarret A, Jackson R, Duizer C, Healy M, Zhao J, Rone J, et al.
Cell
. 2020 Feb;
180(4):813-814.
PMID: 32084342
No abstract available.
9.
Jarret A, Jackson R, Duizer C, Healy M, Zhao J, Rone J, et al.
Cell
. 2020 Jan;
180(1):50-63.e12.
PMID: 31923399
Mucosal barrier immunity is essential for the maintenance of the commensal microflora and combating invasive bacterial infection. Although immune and epithelial cells are thought to be the canonical orchestrators of...
10.
Kaklamanos A, Rozman J, Roulis M, Karagianni N, Armaka M, Wu M, et al.
Sci Rep
. 2017 May;
7(1):2397.
PMID: 28546545
The human growth hormone (hGH) minigene used for transgene stabilization in mice has been recently identified to be locally expressed in the tissues where transgenes are active and associated with...