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Manoj Hariharan

Explore the profile of Manoj Hariharan including associated specialties, affiliations and a list of published articles. Areas
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Articles 29
Citations 5404
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Recent Articles
1.
Comendul A, Ruf-Zamojski F, Ford C, Agarwal P, Zaslavsky E, Nudelman G, et al.
STAR Protoc . 2025 Jan; 6(1):103607. PMID: 39869481
Host response to environmental exposures such as pathogens and chemicals can include modifications to the epigenome and transcriptome. Improved signature discovery, including the identification of the agent and timing of...
2.
Wang W, Hariharan M, Ding W, Bartlett A, Barragan C, Castanon R, et al.
bioRxiv . 2023 Jul; PMID: 37425926
The epigenomic landscape of human immune cells is dynamically shaped by both genetic factors and environmental exposures. However, the relative contributions of these elements are still not fully understood. In...
3.
He Y, Hariharan M, Gorkin D, Dickel D, Luo C, Castanon R, et al.
Nature . 2020 Jul; 583(7818):752-759. PMID: 32728242
Cytosine DNA methylation is essential for mammalian development but understanding of its spatiotemporal distribution in the developing embryo remains limited. Here, as part of the mouse Encyclopedia of DNA Elements...
4.
Ma H, ONeil R, Marti Gutierrez N, Hariharan M, Zhang Z, He Y, et al.
Cell Stem Cell . 2016 Nov; 20(1):112-119. PMID: 27840020
Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional...
5.
Schultz M, He Y, Whitaker J, Hariharan M, Mukamel E, Leung D, et al.
Nature . 2015 Nov; 530(7589):242. PMID: 26605523
No abstract available.
6.
Schultz M, He Y, Whitaker J, Hariharan M, Mukamel E, Leung D, et al.
Nature . 2015 Jun; 523(7559):212-6. PMID: 26030523
Understanding the diversity of human tissues is fundamental to disease and requires linking genetic information, which is identical in most of an individual's cells, with epigenetic mechanisms that could have...
7.
Leung D, Jung I, Rajagopal N, Schmitt A, Selvaraj S, Lee A, et al.
Nature . 2015 Feb; 518(7539):350-354. PMID: 25693566
Allelic differences between the two homologous chromosomes can affect the propensity of inheritance in humans; however, the extent of such differences in the human genome has yet to be fully...
8.
Ma H, Morey R, ONeil R, He Y, Daughtry B, Schultz M, et al.
Nature . 2014 Jul; 511(7508):177-83. PMID: 25008523
Human pluripotent stem cells hold potential for regenerative medicine, but available cell types have significant limitations. Although embryonic stem cells (ES cells) from in vitro fertilized embryos (IVF ES cells)...
9.
Laddha S, Nayak S, Paul D, Reddy R, Sharma C, Jha P, et al.
Biol Direct . 2013 Apr; 8:10. PMID: 23618224
Background: MicroRNAs (miRNAs) are non-uniformly distributed in genomes and ~30% of the miRNAs in the human genome are clustered. In this study we have focused on the imprinted miRNA cluster...
10.
Soon W, Hariharan M, Snyder M
Mol Syst Biol . 2013 Jan; 9:640. PMID: 23340846
Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High-throughput sequencing technologies are...