Manoela Ortega
Overview
Explore the profile of Manoela Ortega including associated specialties, affiliations and a list of published articles.
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Articles
2
Citations
79
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Recent Articles
1.
Lin A, Abbas S, Kim S, Ortega M, Bouamar H, Escobedo Y, et al.
Nat Commun
. 2015 Jul;
6:7768.
PMID: 26178471
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG). In cancer, mutant IDH1/2 reduces α-KG to D2-hydroxyglutarate (D2-HG) disrupting α-KG-dependent dioxygenases. However, the physiological relevance of controlling the interconversion of D2-HG...
2.
Bouamar H, Jiang D, Wang L, Lin A, Ortega M, Aguiar R
Mol Cell Biol
. 2015 Feb;
35(8):1329-40.
PMID: 25645925
In biological processes, the balance between positive and negative inputs is critical for an effective physiological response and to prevent disease. A case in point is the germinal center (GC)...