Manfred Schwab
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Explore the profile of Manfred Schwab including associated specialties, affiliations and a list of published articles.
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64
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1630
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Recent Articles
11.
Blumrich A, Zapatka M, Brueckner L, Zheglo D, Schwab M, Savelyeva L
Hum Mol Genet
. 2011 Jan;
20(8):1488-501.
PMID: 21258086
Common fragile sites (cFS) represent chromosomal regions that are prone to breakage after partial inhibition of DNA synthesis. Activation of cFS is associated with various forms of DNA instability in...
12.
Oberthuer A, Hero B, Berthold F, Juraeva D, Faldum A, Kahlert Y, et al.
J Clin Oncol
. 2010 Jun;
28(21):3506-15.
PMID: 20567016
Purpose: To evaluate the impact of a predefined gene expression-based classifier for clinical risk estimation and cytotoxic treatment decision making in neuroblastoma patients. Patients And Methods: Gene expression profiles of...
13.
Muth D, Ghazaryan S, Eckerle I, Beckett E, Pohler C, Batzler J, et al.
Cancer Res
. 2010 Apr;
70(9):3791-802.
PMID: 20424123
The cell cycle regulator, SKP2, is overexpressed in various cancers and plays a key role in p27 degradation, which is involved in tumor cell dedifferentiation. Little is known about the...
14.
Porro A, Haber M, Diolaiti D, Iraci N, Henderson M, Gherardi S, et al.
J Biol Chem
. 2010 Mar;
285(25):19532-43.
PMID: 20233711
Increased expression of specific ATP-binding cassette (ABC) transporters is known to mediate the efflux of chemotherapeutic agents from cancer cells. Therefore, establishing how ABC transporter genes are controlled at their...
15.
Eckerle I, Muth D, Batzler J, Henrich K, Lutz W, Fischer M, et al.
Cancer Lett
. 2009 Jun;
285(1):99-107.
PMID: 19497660
We analysed the expression of BIRC5 and BIRC5-2B in primary neuroblastoma (NB) tumors and NB model systems. In tumors, overexpression of BIRC5 correlated closely with its isoform BIRC5-2B. Expression of...
16.
Theissen J, Boensch M, Spitz R, Betts D, Stegmaier S, Christiansen H, et al.
Clin Cancer Res
. 2009 Mar;
15(6):2085-90.
PMID: 19276282
Purpose: MYCN amplification is an important therapy-stratifying marker in neuroblastoma. Fluorescence in situ hybridization with signal detection on the single-cell level allows a critical judgement of MYCN intratumoral heterogeneity. Experimental...
17.
Westermann F, Muth D, Benner A, Bauer T, Henrich K, Oberthuer A, et al.
Genome Biol
. 2008 Oct;
9(10):R150.
PMID: 18851746
Background: Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20% of neuroblastomas and identifies a highly aggressive subtype. In MYCN single-copy neuroblastomas, elevated MYCN mRNA and...
18.
Praml C, Schulz W, Claas A, Mollenhauer J, Poustka A, Ackermann R, et al.
Cancer Lett
. 2008 Aug;
272(1):160-6.
PMID: 18752886
AFAR genes play a key role in the detoxification of the carcinogen Aflatoxin B(1) (AFB(1)). In the rat, Afar1 induction can prevent AFB(1)-induced liver cancer. It has been proposed that...
19.
Nevo I, Sagi-Assif O, Botzer L, Amar D, Maman S, Kariv N, et al.
Neoplasia
. 2008 Aug;
10(8):816-27.
PMID: 18683320
Neuroblastoma (NB) is the most commonly occurring solid tumor in children. The disease usually arises in the adrenal medulla, and it is characterized by a remarkable heterogeneity in its progression....
20.
Sagulenko V, Muth D, Sagulenko E, Paffhausen T, Schwab M, Westermann F
Carcinogenesis
. 2008 Jun;
29(10):1869-77.
PMID: 18566016
High incidence of chemotherapy resistance is the primary cause of treatment failure in a subset of neuroblastomas with amplified MYCN. We have reported previously that ectopic MYCN expression promotes proliferation...