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Malcolm E Winkler

Explore the profile of Malcolm E Winkler including associated specialties, affiliations and a list of published articles. Areas
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Articles 92
Citations 3402
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Recent Articles
1.
McQuillen R, Perez A, Yang X, Bohrer C, Smith E, Chareyre S, et al.
Nat Commun . 2024 Dec; 15(1):10746. PMID: 39737933
Most bacteria lack membrane-enclosed organelles and rely on macromolecular scaffolds at different subcellular locations to recruit proteins for specific functions. Here, we demonstrate that the optogenetic CRY2-CIB1 system from Arabidopsis...
2.
De Lay N, Verma N, Sinha D, Garrett A, Osterberg M, Porter D, et al.
PLoS Pathog . 2024 Oct; 20(10):e1012165. PMID: 39361718
Zinc is a vital transition metal for all bacteria; however, elevated intracellular free Zn levels can result in mis-metalation of Mn-dependent enzymes. For Mn-centric bacteria such as Streptococcus pneumoniae that...
3.
Stauberova V, Kubesa B, Joseph M, Benedet M, Furlan B, Buriankova K, et al.
J Mol Biol . 2024 Sep; 436(22):168797. PMID: 39303764
StkP, the Ser/Thr protein kinase of the major human pathogen Streptococcus pneumoniae, monitors cell wall signals and regulates growth and division in response. In vivo, StkP interacts with GpsB, a...
4.
Jiang W, Lin T, Pan J, Rivera C, Tincher C, Wang Y, et al.
Mar Life Sci Technol . 2024 Sep; 6(3):576-577. PMID: 39219682
[This corrects the article DOI: 10.1007/s42995-024-00220-6.].
5.
Perez A, Lamanna M, Bruce K, Touraev M, Page J, Shaw S, et al.
Proc Natl Acad Sci U S A . 2024 Jun; 121(25):e2401831121. PMID: 38875147
Ovoid-shaped bacteria, such as (pneumococcus), have two spatially separated peptidoglycan (PG) synthase nanomachines that locate zonally to the midcell of dividing cells. The septal PG synthase bPBP2x:FtsW closes the septum...
6.
Jiang W, Lin T, Pan J, Rivera C, Tincher C, Wang Y, et al.
Mar Life Sci Technol . 2024 Jun; 6(2):198-211. PMID: 38827133
Supplementary Information: The online version contains supplementary material available at 10.1007/s42995-024-00220-6.
7.
Rahman M, Zamakhaeva S, Rush J, Chaton C, Kenner C, Hla Y, et al.
bioRxiv . 2024 May; PMID: 38746434
Proteins harboring intrinsically disordered regions (IDRs) lacking stable secondary or tertiary structures are abundant across the three domains of life. These regions have not been systematically studied in prokaryotes. Our...
8.
Jaroch M, Sun G, Tsui H, Reed C, Sun J, Jorg M, et al.
J Bacteriol . 2024 Mar; 206(4):e0045223. PMID: 38551342
The wobble bases of tRNAs that decode split codons are often heavily modified. In bacteria, tRNA contains a variety of xnmsU derivatives. The synthesis pathway for these modifications is complex...
9.
Perez A, Lamanna M, Bruce K, Touraev M, Page J, Shaw S, et al.
bioRxiv . 2024 Feb; PMID: 38328058
Ovoid-shaped bacteria, such as (pneumococcus), have two spatially separated peptidoglycan (PG) synthase nanomachines that locate zonally to the midcell of dividing cells. The septal PG synthase bPBP2x:FtsW closes the septum...
10.
Jaroch M, Sun G, Tsui H, Reed C, Sun J, Jorg M, et al.
bioRxiv . 2024 Jan; PMID: 38187551
Importance: The xnm s U modifications found in several tRNAs at the wobble base position are widespread in Bacteria where they have an important role in decoding efficiency and accuracy....