Makoto Fushimi
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Explore the profile of Makoto Fushimi including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
155
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Recent Articles
1.
Sun S, Fushimi M, Rossetti T, Kaur N, Ferreira J, Miller M, et al.
J Chem Inf Model
. 2024 Jan;
64(3):1106.
PMID: 38258980
No abstract available.
2.
Horwitz M, Durr A, Afratis K, Chen Z, Soika J, Christensen K, et al.
J Am Chem Soc
. 2023 Apr;
145(17):9708-9717.
PMID: 37079853
The controlled programming of regiochemical outcomes in nucleophilic fluorination reactions with alkali metal fluoride is a problem yet to be solved. Herein, two synergistic approaches exploiting hydrogen bonding catalysis are...
3.
Sun S, Fushimi M, Rossetti T, Kaur N, Ferreira J, Miller M, et al.
J Chem Inf Model
. 2023 Apr;
63(9):2828-2841.
PMID: 37060320
Free energy perturbation is a computational technique that can be used to predict how small changes to an inhibitor structure will affect the binding free energy to its target. In...
4.
Miller M, Rossetti T, Ferreira J, Ghanem L, Balbach M, Kaur N, et al.
J Med Chem
. 2022 Nov;
65(22):15208-15226.
PMID: 36346696
Soluble adenylyl cyclase (sAC: ADCY10) is an enzyme involved in intracellular signaling. Inhibition of sAC has potential therapeutic utility in a number of areas. For example, sAC is integral to...
5.
Balbach M, Ghanem L, Rossetti T, Kaur N, Ritagliati C, Ferreira J, et al.
Mol Hum Reprod
. 2021 Aug;
27(9).
PMID: 34463764
Soluble adenylyl cyclase (sAC: ADCY10) has been genetically confirmed to be essential for male fertility in mice and humans. In mice, ex vivo studies of dormant, caudal epididymal sperm demonstrated...
6.
Fushimi M, Buck H, Balbach M, Gorovyy A, Ferreira J, Rossetti T, et al.
ACS Med Chem Lett
. 2021 Aug;
12(8):1283-1287.
PMID: 34413957
Soluble adenylyl cyclase (sAC) has gained attention as a potential therapeutic target given the role of this enzyme in intracellular signaling. We describe successful efforts to design improved sAC inhibitors...
7.
Tawada M, Fushimi M, Masuda K, Sun H, Uchiyama N, Kosugi Y, et al.
J Med Chem
. 2021 Jan;
64(2):1103-1115.
PMID: 33404239
-GlcNAcase (OGA) has received increasing attention as an attractive therapeutic target for tau-mediated neurodegenerative disorders; however, its role in these pathologies remains unclear. Therefore, potent chemical tools with favorable pharmacokinetic...
8.
Hidaka T, Imamura K, Hioki T, Takagi T, Giga Y, Giga M, et al.
Patterns (N Y)
. 2020 Dec;
1(9):100140.
PMID: 33336198
Machine learning is expected to improve low throughput and high assay cost in cell-based phenotypic screening. However, it is still a challenge to apply machine learning to achieving sufficiently complex...
9.
Balbach M, Fushimi M, Huggins D, Steegborn C, Meinke P, Levin L, et al.
Biol Reprod
. 2020 Apr;
103(2):176-182.
PMID: 32307523
Efforts to develop new male or female nonhormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by...
10.
Mandai T, Sako Y, Kurimoto E, Shimizu Y, Nakamura M, Fushimi M, et al.
Pharmacol Res Perspect
. 2020 Jan;
8(1):e00560.
PMID: 31990455
M muscarinic acetylcholine receptor (M R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M R activation causes gastrointestinal (GI)...