Mairi Brittan
Overview
Explore the profile of Mairi Brittan including associated specialties, affiliations and a list of published articles.
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59
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1229
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Recent Articles
1.
Barton A, Craig N, Loganath K, Joshi S, Tsampasian V, Mahendran M, et al.
J Am Coll Cardiol
. 2025 Jan;
85(6):578-591.
PMID: 39772364
Background: Myocardial fibrosis is a key healing response after myocardial infarction driven by activated fibroblasts. Gallium-68-labeled fibroblast activation protein inhibitor ([Ga]-FAPI) is a novel positron-emitting radiotracer that binds activated fibroblasts....
2.
Lin A, Brittan M, Baker A, Dimmeler S, Fisher E, Sluimer J, et al.
JACC Basic Transl Sci
. 2024 Feb;
9(1):120-144.
PMID: 38362345
Clonal expansion refers to the proliferation and selection of advantageous "clones" that are better suited for survival in a Darwinian manner. In recent years, we have greatly enhanced our understanding...
3.
Nash J, Meah M, Whittington B, Debono S, Raftis J, Miller M, et al.
Arterioscler Thromb Vasc Biol
. 2024 Feb;
44(4):987-996.
PMID: 38357820
Background: BMS-986141 is a novel potent highly selective antagonist of PAR (protease-activated receptor) type 4. PAR4 antagonism has been demonstrated to reduce thrombus formation in isolation and in combination with...
4.
Passi R, Cholewa-Waclaw J, Wereski R, Bennett M, Veizades S, Berkeley B, et al.
Vascul Pharmacol
. 2024 Jan;
154:107277.
PMID: 38266794
Background: COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect multiple organ systems, including the pulmonary vasculature. Endothelial cells (ECs) are thought to play a key role...
5.
Kesidou D, Bennett M, Monteiro J, McCracken I, Klimi E, Rodor J, et al.
Mol Ther
. 2023 Dec;
32(1):185-203.
PMID: 38096818
Extracellular vesicles (EVs) released from healthy endothelial cells (ECs) have shown potential for promoting angiogenesis, but their therapeutic efficacy remains poorly understood. We have previously shown that transplantation of a...
6.
Li Z, Brittan M, Mills N
Cardiovasc Drugs Ther
. 2023 Jul;
38(2):223-236.
PMID: 37421484
Ischaemic heart disease is a global healthcare challenge with high morbidity and mortality. Early revascularisation in acute myocardial infarction has improved survival; however, limited regenerative capacity and microvascular dysfunction often...
7.
Berkeley B, Tang M, Brittan M
J Pathol
. 2023 Jun;
260(5):666-678.
PMID: 37272582
Myocardial infarction, caused by a thrombus or coronary vascular occlusion, leads to irreversible ischaemic injury. Advances in early reperfusion strategies have significantly reduced short-term mortality after myocardial infarction. However, survivors...
8.
Passi R, Brittan M, Baker A
Curr Opin Physiol
. 2023 May;
34:100670.
PMID: 37159613
Endothelial cell (EC) dysfunction is a characteristic complication of coronavirus-19 (COVID-19). This review discusses the role of the endothelium during the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),...
9.
Spiroski A, McCracken I, Thomson A, Magalhaes-Pinto M, Lalwani M, Newton K, et al.
Front Cardiovasc Med
. 2022 Oct;
9:953211.
PMID: 36299872
Background: Mechanisms contributing to tissue remodeling of the infarcted heart following cell-based therapy remain elusive. While cell-based interventions have the potential to influence the cardiac healing process, there is little...
10.
Li Z, Solomonidis E, Berkeley B, Tang M, Stewart K, Perez-Vicencio D, et al.
Cardiovasc Res
. 2022 Sep;
119(1):136-154.
PMID: 36082978
Aim: Myocardial infarction remains the leading cause of heart failure. The adult human heart lacks the capacity to undergo endogenous regeneration. New blood vessel growth is integral to regenerative medicine...