Mahrukh K Ganapathi
Overview
Explore the profile of Mahrukh K Ganapathi including associated specialties, affiliations and a list of published articles.
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26
Citations
395
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Recent Articles
1.
Norris E, Patel Y, Klotz K, Steuerwald N, Jones W, Maciejewski J, et al.
Leuk Lymphoma
. 2020 Oct;
62(2):473-477.
PMID: 33064055
No abstract available.
2.
Ganapathi R, Norris E, Sutker A, Klotz K, Ganapathi M
Front Oncol
. 2020 Sep;
10:1354.
PMID: 32974133
Aurora A kinase (AAK) involved in G-M transition is functionally involved in centrosome maturation and maintaining an active spindle assembly checkpoint. We tested the hypothesis that in platinum-taxane resistant high...
3.
Michelson A, McDonough S, Willman C, Koegle E, Godwin J, Petersdorf S, et al.
Sci Rep
. 2020 Mar;
10(1):5486.
PMID: 32218491
Anthracyclines used in the treatment of acute myelogenous leukemia (AML) inhibit the activity of the mammalian topoisomerase II (topo II) isoforms, topo II α and topo IIβ. In 230 patients...
4.
Jones W, Michener C, Biscotti C, Braicu I, Sehouli J, Ganapathi M, et al.
Cancers (Basel)
. 2020 Mar;
12(3).
PMID: 32156016
Immune cell infiltrates within the tumor microenvironment can influence treatment response and outcome in several cancers. In this study, we developed RNA-based immune signatures from pan-cancer analysis that could serve...
5.
Norris E, Zhang Q, Jones W, DeStephanis D, Sutker A, Livasy C, et al.
J Pathol
. 2019 Mar;
248(3):352-362.
PMID: 30883751
High grade serous ovarian carcinoma (HGSC) without identifiable serous tubal intraepithelial carcinoma (STIC) within the fallopian tube (FT) occurs in approximately 50% of patients. The objective of this study was...
6.
Patel J, Braicu I, Timms K, Solimeno C, Tshiaba P, Reid J, et al.
Br J Cancer
. 2018 Oct;
119(9):1060-1066.
PMID: 30318511
Background: Homologous recombination deficiency (HRD) is shown to predict response to DNA-damaging therapies in patients with high-grade serous ovarian cancer (HGSOC); however, changes in HRD during progression remains unknown. Methods:...
7.
Norris E, Jones W, Surleac M, Petrescu A, DeStephanis D, Zhang Q, et al.
Gynecol Oncol Rep
. 2018 Jun;
23:41-44.
PMID: 29892687
Neurofibromatosis type 1 (NF1) is caused by mutations in the gene encoding neurofibromin, which negatively regulates Ras signaling. NF1 patients have an increased risk of developing early onset breast cancer,...
8.
Miller K, Patel J, Zhang Q, Norris E, Symanowski J, Michener C, et al.
Gynecol Oncol
. 2018 Feb;
149(1):155-162.
PMID: 29402501
Objectives: Aberrant homeobox (HOX) gene expression is reported in high-grade serous ovarian carcinoma (HGSOC), however, its prognostic significance remains unclear. Methods: HOX genes associated with progression-free survival (PFS) in a...
9.
Kozuki T, Chikamori K, Surleac M, Micluta M, Petrescu A, Norris E, et al.
Nucleic Acids Res
. 2017 May;
45(10):5995-6010.
PMID: 28472494
Topoisomerase (topo) IIα and IIβ maintain genome stability and are targets for anti-tumor drugs. In this study, we demonstrate that the decatenation checkpoint is regulated, not only by topo IIα,...
10.
Miller K, Patel J, Ganapathi M, Tait D, Ganapathi R
Gynecol Oncol
. 2016 Mar;
141(3):608-615.
PMID: 26957480
Homeobox (HOX) genes are a family of transcription factors that are essential regulators of development. HOX genes play important roles in normal reproductive physiology, as well as in the development...