Mahmoud L Nasr
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Explore the profile of Mahmoud L Nasr including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
509
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Recent Articles
1.
Obayashi E, Luna R, Nagata T, Martin-Marcos P, Hiraishi H, Singh C, et al.
Cell Rep
. 2024 Jun;
43(6):114404.
PMID: 38878291
No abstract available.
2.
Elzoghby A, Samir O, Emam H, Soliman A, Abdelgalil R, Elmorshedy Y, et al.
Acta Pharm Sin B
. 2024 Jun;
14(6):2475-2504.
PMID: 38828160
Resistance to cancer immunotherapy is mainly attributed to poor tumor immunogenicity as well as the immunosuppressive tumor microenvironment (TME) leading to failure of immune response. Numerous therapeutic strategies including chemotherapy,...
3.
Mabrouk M, Zidan A, Aly N, Mohammed M, Ghantous F, Seaman M, et al.
Vaccines (Basel)
. 2023 Nov;
11(11).
PMID: 38005987
The emergence of vaccine-evading SARS-CoV-2 variants urges the need for vaccines that elicit broadly neutralizing antibodies (bnAbs). Here, we assess covalently circularized nanodiscs decorated with recombinant SARS-CoV-2 spike glycoproteins from...
4.
Elbahnasawy M, Nasr M
Front Chem
. 2023 Feb;
10:1047874.
PMID: 36844038
Lipid-bilayer nanodiscs and liposomes have been developed to stabilize membrane proteins in order to study their structures and functions. Nanodiscs are detergent-free, water-soluble, and size-controlled planar phospholipid-bilayer platforms. On the...
5.
Elzoghby A, Ferrone C, Ferrone S, Nasr M
Drug Discov Today
. 2022 Nov;
28(1):103434.
PMID: 36368630
Pancreatic cancer (PC) is a highly aggressive malignant type of cancer. Although immunotherapy has been successfully used for treatment of many cancer types, many challenges limit its success in PC....
6.
Zhang M, Gui M, Wang Z, Gorgulla C, Yu J, Wu H, et al.
Nat Struct Mol Biol
. 2021 Feb;
28(3):258-267.
PMID: 33633398
G-protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane proteins and the targets of over 30% of currently marketed pharmaceuticals. Although several structures have been solved for GPCR-G protein complexes,...
7.
Tyukhtenko S, Ma X, Rajarshi G, Karageorgos I, Anderson K, Hudgens J, et al.
Sci Rep
. 2020 Oct;
10(1):18531.
PMID: 33116203
Inhibition of human Monoacylglycerol Lipase (hMGL) offers a novel approach for treating neurological diseases. The design of inhibitors, targeting active-inactive conformational transitions of the enzyme, can be aided by understanding...
8.
Mori Y, Fink C, Ichimura T, Sako K, Mori M, Lee N, et al.
medRxiv
. 2020 Sep;
PMID: 32995803
SARS-CoV-2 precipitates respiratory distress by infection of airway epithelial cells and is often accompanied by acute kidney injury. We report that Kidney Injury Molecule-1/T cell immunoglobulin mucin domain 1 (KIM-1/TIM-1)...
9.
Padmanabha Das K, Shih W, Wagner G, Nasr M
Front Bioeng Biotechnol
. 2020 Jun;
8:539.
PMID: 32596222
Phospho-lipid bilayer nanodiscs have gathered much scientific interest as a stable and tunable membrane mimetic for the study of membrane proteins. Until recently the size of the nanodiscs that could...
10.
Nasr M
Curr Opin Struct Biol
. 2020 Feb;
60:150-156.
PMID: 32066086
Covalently circularized and DNA-corralled nanodisc technologies have enabled engineering of large-sized bilayer nanodiscs up to 90nm. These large nanodiscs have the potential to extend the applicability of nanodisc technology from...