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Mahmoud E Youssef

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Articles 28
Citations 218
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Recent Articles
1.
Saber S, Abdelhady R, Elhemely M, Elmorsy E, Hamad R, Abdel-Reheim M, et al.
Front Pharmacol . 2024 Nov; 15:1475998. PMID: 39564119
Heat shock protein 90 (HSP90) is a pivotal molecular chaperone with multifaceted roles in cellular health and disease. Herein, we explore how HSP90 orchestrates cellular stress responses, particularly through its...
2.
Mohammed O, Youssef M, Hamad R, Abdel-Reheim M, Saleh L, Alamri M, et al.
PLoS One . 2024 Oct; 19(10):e0312572. PMID: 39480853
The development of new drugs for the inhibition of hepatocellular carcinoma (HCC) development and progression is a critical and urgent need. The median survival rate for HCC patients remains disappointingly...
3.
Elmorsy E, Saber S, Hamad R, Abdel-Reheim M, El-Kott A, Alshehri M, et al.
Eur J Pharm Sci . 2024 Oct; 203:106939. PMID: 39423903
Cisplatin, a widely used chemotherapeutic agent, has proven efficacy against various malignancies. However, its clinical utility is hampered by its dose-limiting toxicities, including nephrotoxicity, ototoxicity, neurotoxicity, and myelosuppression. This review...
4.
Elmorsy E, Youssef M, Abdel-Hamed M, Amer M, Elghandour S, Alkhamiss A, et al.
Front Pharmacol . 2024 Oct; 15:1456058. PMID: 39359253
Ulcerative colitis (UC) is a debilitating chronic disease marked by persistent inflammation and intestinal fibrosis. Despite the availability of various treatments, many patients fail to achieve long-term remission, underscoring a...
5.
Cavalu S, Saber S, Ramadan A, Elmorsy E, Hamad R, Abdel-Reheim M, et al.
FASEB J . 2024 Sep; 38(17):e70030. PMID: 39221499
Citicoline, a compound produced naturally in small amounts in the human body, assumes a pivotal role in phosphatidylcholine synthesis, a dynamic constituent of membranes of neurons. Across diverse models of...
6.
Elmorsy E, Saber S, Hamad R, Abdel-Reheim M, El-Kott A, Alshehri M, et al.
Eur J Pharm Sci . 2024 Jul; 200:106849. PMID: 38992452
Doxorubicin (DOX) is an anthracycline chemotherapy drug widely employed in the treatment of various cancers, known for its potent antineoplastic properties but often associated with dose-dependent cardiotoxicity, limiting its clinical...
7.
Mohammed O, Youssef M, Doghish A, Hamad R, Abdel-Reheim M, Alghamdi M, et al.
Eur J Pharm Sci . 2024 May; 198:106792. PMID: 38714237
Non-alcoholic steatohepatitis (NASH) is characterized by liver inflammation, fat accumulation, and collagen deposition. Due to the limited availability of effective treatments, there is a pressing need to develop innovative strategies....
8.
Cavalu S, Saber S, Hamad R, Abdel-Reheim M, Elmorsy E, Youssef M
Front Cell Neurosci . 2024 May; 18:1336145. PMID: 38699177
The orexins, also referred to as hypocretins, are neuropeptides that originate from the lateral hypothalamus (LH) region of the brain. They are composed of two small peptides, orexin-A, and orexin-B,...
9.
Mohammed O, Saber S, Abdel-Reheim M, Alamri M, Alfaifi J, Adam M, et al.
Toxicol Appl Pharmacol . 2024 Apr; 486:116943. PMID: 38677600
Ulcerative colitis (UC) is an inflammatory condition that affects the colon's lining and increases the risk of colon cancer. Despite ongoing research, there is no identified cure for UC. The...
10.
Youssef M, Yahya G, Popoviciu M, Cavalu S, Abd-Eldayem M, Saber S
Int J Mol Sci . 2023 Apr; 24(7). PMID: 37047011
The number of diabetic patients has risen dramatically in recent decades, owing mostly to the rising incidence of type 2 diabetes mellitus (T2DM). Several oral antidiabetic medications are used for...