Madeline N Hayes
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Explore the profile of Madeline N Hayes including associated specialties, affiliations and a list of published articles.
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11
Citations
441
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Recent Articles
1.
Weiss A, DAmata C, Pearson B, Hayes M
Elife
. 2024 Jul;
13.
PMID: 39052000
High-throughput vertebrate animal model systems for the study of patient-specific biology and new therapeutic approaches for aggressive brain tumors are currently lacking, and new approaches are urgently needed. Therefore, to...
2.
Valencia-Sama I, Kee L, Christopher G, Ohh M, Layeghifard M, Shlien A, et al.
Cancer Res Commun
. 2023 Nov;
3(12):2608-2622.
PMID: 38032104
Significance: These findings highlight the translatability between zebrafish and murine models, provide evidence of aberrant RAS-MAPK signaling as an adaptive mechanism of resistance to lorlatinib, and demonstrate the clinical potential...
3.
Chen J, Baxi K, Lipsitt A, Hensch N, Wang L, Sreenivas P, et al.
Elife
. 2023 Jun;
12.
PMID: 37266578
In embryonal rhabdomyosarcoma (ERMS) and generally in sarcomas, the role of wild-type and loss- or gain-of-function mutations remains largely undefined. Eliminating mutant or restoring wild-type p53 is challenging; nevertheless, understanding...
4.
Wei Y, Qin Q, Yan C, Hayes M, Garcia S, Xi H, et al.
Nat Cancer
. 2022 Aug;
3(8):961-975.
PMID: 35982179
Rhabdomyosarcoma (RMS) is a common childhood cancer that shares features with developing skeletal muscle. Yet, the conservation of cellular hierarchy with human muscle development and the identification of molecularly defined...
5.
Yohe M, Heske C, Stewart E, Adamson P, Ahmed N, Antonescu C, et al.
Pediatr Blood Cancer
. 2019 Jun;
66(10):e27869.
PMID: 31222885
Overall survival rates for pediatric patients with high-risk or relapsed rhabdomyosarcoma (RMS) have not improved significantly since the 1980s. Recent studies have identified a number of targetable vulnerabilities in RMS,...
6.
Yan C, Brunson D, Tang Q, Do D, Iftimia N, Moore J, et al.
Cell
. 2019 Apr;
177(7):1903-1914.e14.
PMID: 31031007
Xenograft cell transplantation into immunodeficient mice has become the gold standard for assessing pre-clinical efficacy of cancer drugs, yet direct visualization of single-cell phenotypes is difficult. Here, we report an...
7.
Ignatius M, Hayes M, Moore F, Tang Q, Garcia S, Blackburn P, et al.
Elife
. 2018 Sep;
7.
PMID: 30192230
The tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated deleted zebrafish that spontaneously develop...
8.
Hayes M, McCarthy K, Jin A, Oliveira M, Iyer S, Garcia S, et al.
Cell Stem Cell
. 2018 Mar;
22(3):414-427.e6.
PMID: 29499154
Tumor growth and relapse are driven by tumor propagating cells (TPCs). However, mechanisms regulating TPC fate choices, maintenance, and self-renewal are not fully understood. Here, we show that Van Gogh-like...
9.
Ignatius M, Hayes M, Lobbardi R, Chen E, McCarthy K, Sreenivas P, et al.
Cell Rep
. 2017 Jun;
19(11):2304-2318.
PMID: 28614716
Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. However, mechanisms regulating TPC self-renewal are largely unknown, especially in embryonal rhabdomyosarcoma (ERMS)-a common pediatric...
10.
Tenente I, Hayes M, Ignatius M, McCarthy K, Yohe M, Sindiri S, et al.
Elife
. 2017 Jan;
6.
PMID: 28080960
Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of...