Maarten M G van den Hoogenhof
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Explore the profile of Maarten M G van den Hoogenhof including associated specialties, affiliations and a list of published articles.
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14
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672
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Recent Articles
1.
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy
Grosch M, Schraft L, Chan A, Kuchenhoff L, Rapti K, Ferreira A, et al.
Nat Commun
. 2023 Jun;
14(1):3714.
PMID: 37349314
Dilated cardiomyopathy is the second most common cause for heart failure with no cure except a high-risk heart transplantation. Approximately 30% of patients harbor heritable mutations which are amenable to...
2.
Lennermann D, Pepin M, Grosch M, Konrad L, Kemmling E, Hartmann J, et al.
Am J Physiol Heart Circ Physiol
. 2022 Nov;
323(6):H1296-H1310.
PMID: 36367695
cardiomyopathy is an arrhythmogenic form of dilated cardiomyopathy caused by mutations in the splicing factor RBM20. A recent study found a more severe phenotype in male patients with cardiomyopathy patients...
3.
van den Hoogenhof M, Azzouzi H, Beqqali A
Front Genet
. 2021 Oct;
12:775091.
PMID: 34712276
No abstract available.
4.
Duran J, Nickel L, Estrada M, Backs J, van den Hoogenhof M
Front Cell Dev Biol
. 2021 Mar;
9:644630.
PMID: 33777949
RNA splicing has been recognized in recent years as a pivotal player in heart development and disease. The Ca/calmodulin dependent protein kinase II delta (CaMKIIδ) is a multifunctional Ser/Thr kinase...
5.
van den Hoogenhof M, van der Made I, de Groot N, Damanafshan A, van Amersfoorth S, Zentilin L, et al.
Sci Rep
. 2018 Aug;
8(1):11696.
PMID: 30076363
The RNA-binding protein Rbm24 has recently been identified as a pivotal splicing factor in the developing heart. Loss of Rbm24 in mice disrupts cardiac development by governing a large number...
6.
Beckendorf J, van den Hoogenhof M, Backs J
Basic Res Cardiol
. 2018 Jun;
113(4):29.
PMID: 29905892
In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation-contraction and also excitation-transcription coupling. Its activity can be regulated in response to changes in intracellular calcium content...
7.
van den Hoogenhof M, Beqqali A, Amin A, van der Made I, Aufiero S, Khan M, et al.
Circulation
. 2018 Apr;
138(13):1330-1342.
PMID: 29650543
Background: Mutations in RBM20 (RNA-binding motif protein 20) cause a clinically aggressive form of dilated cardiomyopathy, with an increased risk of malignant ventricular arrhythmias. RBM20 is a splicing factor that...
8.
Aufiero S, van den Hoogenhof M, Reckman Y, Beqqali A, van der Made I, Kluin J, et al.
RNA
. 2018 Mar;
24(6):815-827.
PMID: 29567830
Circular RNAs (circRNAs) are a relatively new class of RNA molecules, and knowledge about their biogenesis and function is still in its infancy. It was recently shown that alternative splicing...
9.
van den Hoogenhof M, van der Made I, Beqqali A, de Groot N, Damanafshan A, van Oort R, et al.
PLoS One
. 2017 Aug;
12(8):e0184093.
PMID: 28850611
The importance of tightly controlled alternative pre-mRNA splicing in the heart is emerging. The RNA binding protein Rbm24 has recently been identified as a pivotal cardiac splice factor, which governs...
10.
Khan M, Reckman Y, Aufiero S, van den Hoogenhof M, van der Made I, Beqqali A, et al.
Circ Res
. 2016 Aug;
119(9):996-1003.
PMID: 27531932
Rationale: RNA-binding motif protein 20 (RBM20) is essential for normal splicing of many cardiac genes, and loss of RBM20 causes dilated cardiomyopathy. Given its role in splicing, we hypothesized an...