M T Michalek
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Explore the profile of M T Michalek including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
217
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Recent Articles
1.
Mork A, Helmke R, Martinez J, Michalek M, Patchen M, Zhang G
Immunopharmacology
. 1998 Oct;
40(1):77-89.
PMID: 9776481
Particulate and soluble (1-3)-beta-glucans are effective in preventing infections by enhancing macrophage and neutrophil functions. However, the mechanisms triggering these enhanced cellular responses are essentially unknown. We recently demonstrated that...
2.
Michalek M, Grant E, Rock K
J Immunol
. 1996 Jul;
157(2):617-24.
PMID: 8752909
Class I presentation of microinjected native OVA by a temperature-sensitive ubiquitin conjugation mutant, ts85, but not wild-type murine cells, was markedly inhibited following incubation at a nonpermissive temperature. In contrast,...
3.
Grant E, Michalek M, GOLDBERG A, Rock K
J Immunol
. 1995 Oct;
155(8):3750-8.
PMID: 7561079
The effect on MHC class I Ag presentation of enhancing a protein's rate of degradation by the ubiquitin-proteasome pathway was investigated. In extracts of mouse B-lymphoblasts and reticulocytes, as in...
4.
Michalek M, Grant E, Gramm C, GOLDBERG A, Rock K
Nature
. 1993 Jun;
363(6429):552-4.
PMID: 8389422
The degradation of most cellular proteins starts with their covalent conjugation with ubiquitin. This labels the proteins for rapid hydrolysis to oligopeptides by a (26S) proteolytic complex containing a (20S)...
5.
Michalek M, Benacerraf B, Rock K
J Immunol
. 1992 Feb;
148(4):1016-24.
PMID: 1737924
LB27.4 cells (a B lymphoblastoid APC) were transfected with a plasmid containing an OVA cDNA. Functional analysis of six independent clones yielded three patterns of MHC-restricted presentation of the endogenously...
6.
Michalek M, Benacerraf B, Rock K
J Immunol
. 1991 Jan;
146(2):449-56.
PMID: 1987272
This report describes the effects of NH4Cl, CH3NH2, and chloroquine on class I and II MHC-restricted Ag presentation. OVA-specific T-T hybridomas were used to detect processed OVA in association with...
7.
Dang L, Michalek M, Takei F, Benaceraff B, Rock K
J Immunol
. 1990 Jun;
144(11):4082-91.
PMID: 1971292
We report a methodology for selecting APC with mutations that have impaired their ability to present Ag to T cells. A20 B lymphoblastoid cells were mutagenized and then repeatedly cocultured...
8.
Two genetically identical antigen-presenting cell clones display heterogeneity in antigen processing
Michalek M, Benacerraf B, Rock K
Proc Natl Acad Sci U S A
. 1989 May;
86(9):3316-20.
PMID: 2470101
Evidence from various antigen systems suggests that antigen processing can be one factor that determines the repertoire of immunogenic peptides. Thus, processing events may account for some of the disparity...
9.
Benacerraf B, Michalek M, Dang L, Rock K
Cold Spring Harb Symp Quant Biol
. 1989 Jan;
54 Pt 1:293-8.
PMID: 2700938
No abstract available.
10.
Michalek M, Mold C, Bremer E
J Immunol
. 1988 Mar;
140(5):1588-94.
PMID: 3346543
Liposomes were used to determine whether gangliosides containing certain structurally defined analogues of sialic acid could inhibit activation of the alternative pathway of human C. Gangliosides containing sialic acid residues...