M T Matthes
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Explore the profile of M T Matthes including associated specialties, affiliations and a list of published articles.
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25
Citations
1578
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Recent Articles
1.
Duncan K, Hosseini K, Bailey K, Yang H, Lowe R, Matthes M, et al.
Br J Ophthalmol
. 2009 Mar;
93(8):1116-20.
PMID: 19304587
Aims: Excessive lipid accumulation in Bruch's membrane (BrM) is a hallmark of ageing, the major risk factor for age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells may utilise reverse...
2.
Danciger M, Yang H, Ralston R, Liu Y, Matthes M, PEIRCE J, et al.
Mol Vis
. 2007 Feb;
13:79-85.
PMID: 17277741
Purpose: Previously, several quantitative trait loci (QTL) that influence age-related retinal degeneration (ageRD) were demonstrated in a cross between the C57BL/6J-c(2J) and BALB/cByJ strains (B x C). In this study,...
3.
Rohrer B, Matthes M, LaVail M, Reichardt L
Exp Eye Res
. 2003 Feb;
76(1):125-9.
PMID: 12589782
Rod photoreceptors are susceptible to light-induced cell death. Previous results have suggested that the neurotrophin receptor p75 in Müller cells controls photoreceptor cell death during light-exposure by suppressing trophic factor...
4.
Vollrath D, Feng W, Duncan J, Yasumura D, DCruz P, Chappelow A, et al.
Proc Natl Acad Sci U S A
. 2001 Oct;
98(22):12584-9.
PMID: 11592982
The Royal College of Surgeons (RCS) rat is a widely studied animal model of retinal degeneration in which the inability of the retinal pigment epithelium (RPE) to phagocytize shed photoreceptor...
5.
Ren J, Stubbs Jr E, Matthes M, Yasumura D, Naash M, LaVail M, et al.
Exp Eye Res
. 2001 Feb;
72(3):243-52.
PMID: 11180973
We have recently noted that the inner nuclear layer (INL) and the inner plexiform layer (IPL) were significantly thinner in mice homozygous for the nervous defect (nr / nr) than...
6.
LaVail M, Yasumura D, Matthes M, Drenser K, Flannery J, Lewin A, et al.
Proc Natl Acad Sci U S A
. 2000 Sep;
97(21):11488-93.
PMID: 11005848
Ribozyme-directed cleavage of mutant mRNAs appears to be a potentially effective therapeutic measure for dominantly inherited diseases. We previously demonstrated that two ribozymes targeted to the P23H mutation in rhodopsin...
7.
Danciger M, Matthes M, Yasamura D, Akhmedov N, Rickabaugh T, Gentleman S, et al.
Mamm Genome
. 2000 May;
11(6):422-7.
PMID: 10818205
C57BL/6J-c(2J) (c2J) albino mice showed much less damage to their photoreceptors after exposure to prolonged light than BALB/c mice and seven other albino strains tested. There were no gender differences,...
8.
DCruz P, Yasumura D, Weir J, Matthes M, Abderrahim H, LaVail M, et al.
Hum Mol Genet
. 2000 Mar;
9(4):645-51.
PMID: 10699188
Vertebrate photoreceptor cells are the basic sensory apparatus of the retina, capable of converting the energy of absorbed photons into neuronal signals. The proximal portions of mammalian photoreceptor outer segments...
9.
Chen J, Simon M, Matthes M, Yasumura D, LaVail M
Invest Ophthalmol Vis Sci
. 1999 Nov;
40(12):2978-82.
PMID: 10549660
Purpose: To determine whether constitutive signal flow arising from defective rhodopsin shut-off causes photoreceptor cell death in arrestin knockout mice. Methods: The retinas of cyclic-light-reared, pigmented arrestin knockout mice and...
10.
LaVail M, Gorrin G, Yasumura D, Matthes M
Invest Ophthalmol Vis Sci
. 1999 Apr;
40(5):1020-4.
PMID: 10102304
Purpose: To determine whether the degenerating photoreceptors in nervous (nr/nr) and Purkinje cell degeneration (pcd/pcd) mutant mice are more susceptible to the damaging effects of constant light than those in...