M Saksela
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Explore the profile of M Saksela including associated specialties, affiliations and a list of published articles.
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10
Citations
116
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Recent Articles
1.
Cook W, Chu R, Saksela M, Raivio K, Yeldandi A
Int J Oncol
. 2011 Apr;
11(5):1013-7.
PMID: 21528298
Xanthine oxidase (XO) and xanthine dehydrogenase (XDH) are alternate enzymatic forms of the XO/XDH protein that catalyzes the oxidation of hypoxanthine to xanthine, and xanthine to uric acid, and in...
2.
Levonen A, Lapatto R, Saksela M, Raivio K
Biochem J
. 2000 Mar;
347 Pt 1:291-5.
PMID: 10727430
Cystathionine gamma-lyase (CGL) is the last enzyme of the trans-sulphuration pathway, which converts methionine into cysteine. To study the possible differences in enzymic activity of the two human cystathionine gamma-lyase...
3.
Levonen A, Lapatto R, Saksela M, Raivio K
Pediatr Res
. 2000 Feb;
47(2):266-70.
PMID: 10674357
Prematurity has been associated with low glutathione (GSH) concentrations in bronchoalveolar lavage fluid as well as in leukocytes from tracheal aspirates and peripheral blood. To elucidate whether this is caused...
4.
Saksela M, Lapatto R, Raivio K
FEBS Lett
. 1999 Feb;
443(2):117-20.
PMID: 9989587
Irreversible conversion of xanthine dehydrogenase (XDH) to its oxygen free radical producing oxidase (XO) form occurs through an uncharacterized proteolytic process, which was studied in human liver. Upon incubation of...
5.
Asikainen T, Raivio K, Saksela M, Kinnula V
Am J Respir Cell Mol Biol
. 1998 Dec;
19(6):942-9.
PMID: 9843929
Air breathing, especially oxygen therapy, exposes the lung to reactive oxygen species (ROS). Antioxidant enzymes (AOEs) may protect the lung from ROS-mediated injury. Because expression of the key AOEs increases...
6.
Saksela M, Lapatto R, Raivio K
Biol Neonate
. 1998 Aug;
74(4):274-80.
PMID: 9701649
Xanthine oxidoreductase (XOR) has been implicated in tissue injury following ischemia-reperfusion because of its ability to generate reactive oxygen species under these conditions. In order to elucidate its role in...
7.
Raivio K, Saksela M, Asikainen T, Kinnula V
Am J Respir Cell Mol Biol
. 1998 Aug;
19(2):286-92.
PMID: 9698601
Bronchial epithelial cells are the first cells to encounter high concentrations of inspired oxygen, and their damage is a typical feature in many airway diseases. The direct effect of oxygen...
8.
Raivio K, Linnainmaa K, Ekman A, Saksela M, Kinnula V
Cell Biol Toxicol
. 1996 Jun;
12(3):167-75.
PMID: 8817062
We compared induction of manganese superoxide dismutase (MnSOD) by asbestos fibers and tumor necrosis factor alpha (TNF) using cultured human mesothelial cells. Transformed pleural mesothelial cells (MET 5A) were exposed...
9.
Saksela M, Raivio K
Biochem J
. 1996 Apr;
315 ( Pt 1):235-9.
PMID: 8670112
To study the expression of human xanthine dehydrogenase/oxidase (hXDH/XO), we cloned the cDNA covering its complete coding sequence and characterized it by translation in vitro in rabbit reticulocyte lysates and...
10.
Rytkonen E, Halila R, Laan M, Saksela M, Kallioniemi O, Palotie A, et al.
Cytogenet Cell Genet
. 1995 Jan;
68(1-2):61-3.
PMID: 7956361
Mutations in the xanthine dehydrogenase gene (XDH), which codes for the last enzyme of the purine catabolic pathway in man, cause the autosomal recessive disease xanthinuria. We obtained cDNA clones...