M Roy First
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Explore the profile of M Roy First including associated specialties, affiliations and a list of published articles.
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53
Citations
782
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Recent Articles
1.
Govil A, Munda R, First M
Transplant Proc
. 2022 Jan;
54(1):104-106.
PMID: 34972568
Here, we report on the remarkable survival of a simultaneous kidney-pancreas transplant recipient who has received minimal immunosuppression, has had normal kidney function, and has been insulin-free for 40 years...
2.
Kelly C, Murray J, Leffler D, Getts D, Bledsoe A, Smithson G, et al.
Gastroenterology
. 2021 Mar;
161(1):66-80.e8.
PMID: 33722583
Background & Aims: In celiac disease (CeD), gluten induces immune activation, leading to enteropathy. TAK-101, gluten protein (gliadin) encapsulated in negatively charged poly(dl-lactide-co-glycolic acid) nanoparticles, is designed to induce gluten-specific...
3.
Ang A, Schieve C, Rose S, Kew C, First M, Mannon R
Clin Transplant
. 2020 Nov;
35(1):e14145.
PMID: 33170974
Purpose: TruGraf™ blood test measures a specific gene expression signature in peripheral blood mononuclear cells for noninvasive assessment of kidney transplant recipients (KTRs) with stable renal function, excluding subclinical acute...
4.
Lee D, Abecassis M, Friedewald J, Rose S, First M
Transplant Proc
. 2020 Jun;
52(10):3085-3089.
PMID: 32576474
An e-mail-based market research survey focused on high-volume US adult transplant centers was developed and implemented to assess surveillance based on United Network for Organ Sharing/Scientific Registry of Transplant Recipients...
5.
Peddi V, Patel P, Schieve C, Rose S, First M
Ann Transplant
. 2020 Apr;
25:e920839.
PMID: 32341330
BACKGROUND TruGraf is a blood-based biomarker test that measures differential expression of a collection of genes that have been shown to correlate with surveillance biopsy results. However, in the majority...
6.
Stegall M, Somerville K, Everly M, Mannon R, Gaber A, First M, et al.
Am J Transplant
. 2018 Dec;
19(3):625-632.
PMID: 30549395
The Transplant Therapeutics Consortium (TTC) is a public-private partnership between the US Food and Drug Administration and the transplantation community including the transplantation societies and members of the biopharmaceutical industry....
7.
Tanzi M, Undre N, Keirns J, Fitzsimmons W, Brown M, First M
Clin Transplant
. 2016 May;
30(8):901-11.
PMID: 27220013
Prolonged-release tacrolimus was developed as a once-daily formulation with ethylcellulose as the excipient, resulting in slower release and reduction in peak concentration (Cmax ) for a given dose compared with...
8.
Lin S, Henning A, Akhlaghi F, Reisfield R, Vergara-Silva A, First M
Ther Drug Monit
. 2014 Aug;
37(2):206-13.
PMID: 25162212
Background: Tacrolimus (TAC) is a known substrate for cytochrome P450 (CYP) enzyme. CYP enzyme activity can be modulated by activation of IL-2 receptors (IL-2R) expressed on hepatocytes and intestinal cells....
9.
Tedesco Silva Jr H, Yang H, Meier-Kriesche H, Croy R, Holman J, Fitzsimmons W, et al.
Transplantation
. 2014 Feb;
97(6):636-41.
PMID: 24521771
Background: In a phase III, open-label, comparative, noninferiority study, 638 subjects receiving de novo kidney transplants were randomized to one of three treatment arms: tacrolimus extended-release (Astagraf XL) qd, tacrolimus...
10.
First M, Dhadda S, Croy R, Holman J, Fitzsimmons W
Transplantation
. 2013 Apr;
96(1):58-64.
PMID: 23619735
Background: New-onset diabetes after transplantation (NODAT) occurs commonly. Prior NODAT definitions have been inconsistent. Based on the American Diabetic Association criteria, we propose a new approach to defining NODAT. Methods:...