M R Montminy
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Explore the profile of M R Montminy including associated specialties, affiliations and a list of published articles.
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41
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4679
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Recent Articles
1.
Mayr B, Canettieri G, Montminy M
Proc Natl Acad Sci U S A
. 2001 Sep;
98(19):10936-41.
PMID: 11535812
Ser-133 phosphorylation of the cAMP-responsive element-binding protein (CREB) is sufficient to induce cellular gene expression in response to cAMP, but additional promoter-bound factors are required for target gene activation by...
2.
Frangioni J, LaRiccia L, Cantley L, Montminy M
Nat Biotechnol
. 2000 Oct;
18(10):1080-5.
PMID: 11017047
Human gene therapy approaches involving transcription factors often rely on artificial activation domains for transcriptional activation. These domains are often large (e.g., 80 amino acids for VP16), recruit multiple co-activation...
3.
Radhakrishnan I, Parker D, Dyson H, Montminy M, Wright P
J Mol Biol
. 1999 May;
287(5):859-65.
PMID: 10222196
A number of signal-dependent and development-specific transcription factors recruit CREB binding protein (CBP) for their transactivation function. The KIX domain of CBP is a common docking site for many of...
4.
Radhakrishnan I, Parker D, Dyson H, Montminy M, Wright P
Cell
. 1997 Dec;
91(6):741-52.
PMID: 9413984
The nuclear factor CREB activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner. The solution structure of...
5.
Mayall T, Sheridan P, Montminy M, Jones K
Genes Dev
. 1997 Apr;
11(7):887-99.
PMID: 9106660
The distal enhancer of the T-cell receptor (TCR) alpha chain gene has become a paradigm for studies of the assembly and activity of architectural enhancer complexes. Here we have reconstituted...
6.
Nakajima T, Fukamizu A, Takahashi J, Gage F, Fisher T, Blenis J, et al.
Cell
. 1996 Aug;
86(3):465-74.
PMID: 8756728
We have examined the mechanism by which growth factor-mediated induction of the Ras pathway interferes with signaling via the second messenger cAMP. Activation of cellular Ras with insulin or NGF...
7.
Kee B, Arias J, Montminy M
J Biol Chem
. 1996 Feb;
271(5):2373-5.
PMID: 8576192
The second messenger cAMP stimulates the expression of a number of target genes via the protein kinase A-mediated phosphorylation of CREB at Ser-133 (Gonzalez, G. A., and Montminy, M. R....
8.
Parker D, Ferreri K, Nakajima T, LaMorte V, Evans R, Koerber S, et al.
Mol Cell Biol
. 1996 Feb;
16(2):694-703.
PMID: 8552098
We have characterized a phosphoserine binding domain in the coactivator CREB-binding protein (CBP) which interacts with the protein kinase A-phosphorylated, and hence activated, form of the cyclic AMP-responsive factor CREB....
9.
Sharma S, Leonard J, Lee S, Chapman H, Leiter E, Montminy M
J Biol Chem
. 1996 Jan;
271(4):2294-9.
PMID: 8567692
The commitment of cells to specific lineages during development is determined in large part by the relative expression of various homeodomain (HOX) selector proteins, which mediate the activation of distinct...
10.
Guz Y, Montminy M, Stein R, Leonard J, Gamer L, Wright C, et al.
Development
. 1995 Jan;
121(1):11-8.
PMID: 7867492
The XlHbox 8 homeodomain protein of Xenopus and STF-1, its mammalian homolog, are selectively expressed by beta cells of adult mouse pancreatic islets, where they are likely to regulate insulin...