M Pellecchia
Overview
Explore the profile of M Pellecchia including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
763
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0
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Recent Articles
1.
Pal I, Sarkar S, Rajput S, Dey K, Chakraborty S, Dash R, et al.
Br J Cancer
. 2014 Jun;
111(1):101-11.
PMID: 24892445
Background: Akt and its downstream signalling pathways contribute to the aetiology and progression of colorectal carcinoma (CRC). Targeting the Akt pathway is an attractive strategy but few chemotherapeutic drugs have...
2.
Scortegagna M, Ruller C, Feng Y, Lazova R, Kluger H, Li J, et al.
Oncogene
. 2013 Sep;
33(34):4330-9.
PMID: 24037523
Phosphoinositide-dependent kinase-1 (PDK1) is a serine/threonine protein kinase that phosphorylates members of the conserved AGC kinase superfamily, including AKT and protein kinase C (PKC), and is implicated in important cellular...
3.
Varadarajan S, Bampton E, Smalley J, Tanaka K, Caves R, Butterworth M, et al.
Cell Death Differ
. 2012 Sep;
19(12):1896-907.
PMID: 22955944
Canonical endoplasmic reticulum (ER) stress, which occurs in many physiological and disease processes, results in activation of the unfolded protein response (UPR). We now describe a new, evolutionarily conserved cellular...
4.
Targeting the BH3-interacting domain death agonist to develop mechanistically unique antidepressants
Malkesman O, Austin D, Tragon T, Henter I, Reed J, Pellecchia M, et al.
Mol Psychiatry
. 2011 Jul;
17(8):770-80.
PMID: 21727899
The BH3-interacting domain death agonist (Bid) is a pro-apoptotic member of the B-cell lymphoma-2 (Bcl-2) protein family. Previous studies have shown that stress reduces levels of Bcl-2 in brain regions...
5.
Placzek W, Wei J, Kitada S, Zhai D, Reed J, Pellecchia M
Cell Death Dis
. 2011 Mar;
1:e40.
PMID: 21364647
We investigated the mRNA expression levels of all six antiapoptotic Bcl-2 subfamily members in 68 human cancer cell lines using qPCR techniques and measured the ability of known Bcl-2 inhibitors...
6.
Berndt N, Yang H, Trinczek B, Betzi S, Zhang Z, Wu B, et al.
Cell Death Differ
. 2010 May;
17(11):1795-804.
PMID: 20489726
Persistently hyperphosphorylated Akt contributes to human oncogenesis and resistance to therapy. Triciribine (TCN) phosphate (TCN-P), the active metabolite of the Akt phosphorylation inhibitor TCN, is in clinical trials, but the...
7.
Landshamer S, Hoehn M, Barth N, Duvezin-Caubet S, Schwake G, Tobaben S, et al.
Cell Death Differ
. 2008 Jun;
15(10):1553-63.
PMID: 18535584
Mitochondrial dysfunction and release of pro-apoptotic factors such as cytochrome c or apoptosis-inducing factor (AIF) from mitochondria are key features of neuronal cell death. The precise mechanisms of how these...
8.
Negrini R, Milanesi E, Colli L, Pellecchia M, Nicoloso L, Crepaldi P, et al.
Anim Genet
. 2007 Mar;
38(2):147-53.
PMID: 17326802
The verification of the breed origin of animal products is relevant for food safety and authenticity. We assessed the suitability of AFLP molecular markers in the assignment of cattle individuals...
9.
Negri I, Pellecchia M, Mazzoglio P, Patetta A, Alma A
Proc Biol Sci
. 2006 Aug;
273(1599):2409-16.
PMID: 16928646
Zyginidia pullula is a grass-dwelling leafhopper characterized by a bisexual reproduction mode. In this species, some females collected in Northern Italy, when mated with males, gave origin to an exclusively...
10.
Coward L, Gorman G, Noker P, Kerstner-Wood C, Pellecchia M, Reed J, et al.
J Pharm Biomed Anal
. 2006 Jul;
42(5):581-6.
PMID: 16859853
A simple and selective liquid chromatography/tandem mass spectrometry (LC/MS/MS) method based on internal standard quantitation using apigenin as the internal standard has been developed and validated for the analysis of...