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M P Hutt

Explore the profile of M P Hutt including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 31
Citations 219
Followers 0
Related Specialties
Chemistry
General Medicine
Pharmacology
Top 10 Co-Authors
T F Mich
E F Elslager
J P Sanchez
L M Werbel
C L Heifetz
J M Domagala
M Solomon
D F WORTH
T E Starzl
A K Trehan
Published In
J Med Chem
J Antibiot (Tokyo)
Am J Med
Arch Intern Med
Ann N Y Acad Sci
Affiliations
Soon will be listed here.
Recent Articles
1.
THE PROBLEMS AND PROGNOSIS OF THE CHRONICALLY SURVIVING PATIENT AFTER RENAL HOMOTRANSPLANTATION
Starzl T, Marchioro T, Faris T, Hutt M, Carey T, Ogden D, et al.
Ann N Y Acad Sci . 2010 Dec; 129:598-614. PMID: 21188299
No abstract available.
2.
Pulmonary capillaritis. The association with progressive irreversible airflow limitation and hyperinflation
Schwarz M, Mortenson R, Colby T, Waldron J, Lynch D, Hutt M, et al.
Am Rev Respir Dis . 1993 Aug; 148(2):507-11. PMID: 8102044
We report two patients with systemic necrotizing vasculitis (microscopic polyarteritis) and associated recurrent pulmonary capillaritis, in whom progressive irreversible airway dysfunction began approximately 10 yr after disease onset. Their course...
3.
Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine
Kiely J, Hutt M, CULBERTSON T, Bucsh R, WORTH D, Lesheski L, et al.
J Med Chem . 1991 Feb; 34(2):656-63. PMID: 1995890
A series of quinolone and naphthyridine antibacterial agents possessing as the C7-heterocycle bicyclic 2,5-diazabicyclo[n.2.m]alkanes, where n = 2, 3 and m = 1, 2, and a series including 4-aminopiperidine and...
4.
Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids
Sanchez J, Domagala J, Hagen S, Heifetz C, Hutt M, Nichols J, et al.
J Med Chem . 1988 May; 31(5):983-91. PMID: 3361584
A series of 7,8-disubstituted 1-cyclopropyl-6-fluoroquinoline-3-carboxylic acids, 7-substituted 1-cyclopropyl-6-fluoro-1,8-naphthyridine-3-carboxylic acids, and 10-substituted 9-fluoropyridobenzoxazine-6-carboxylic acids has been prepared and evaluated for antibacterial activity. The side chains examined at the 7-position (benzoxazine 10-position)...
5.
1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials
Domagala J, Heifetz C, Hutt M, Mich T, Nichols J, Solomon M, et al.
J Med Chem . 1988 May; 31(5):991-1001. PMID: 2834557
A series of 18 1-substituted 7-[3-[(ethylamino)methyl]-1- pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline- carboxylic acids (N1 analogues of CI-934) were synthesized and evaluated for antibacterial activity and DNA-gyrase inhibition. Correlations between the inhibition of DNA gyrase...
6.
7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials
Domagala J, Hagen S, Heifetz C, Hutt M, Mich T, Sanchez J, et al.
J Med Chem . 1988 Mar; 31(3):503-6. PMID: 3346869
No abstract available.
7.
5-Amino-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acid (PD 124,816). Synthesis and biological evaluation of a new class of quinolone antibacterials
Domagala J, Hagen S, Hutt M, Sanchez J, Sesnie J, Trehan A
Drugs Exp Clin Res . 1988 Jan; 14(7):453-60. PMID: 2853667
A series of 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids with piperazinyl or pyrrolidinyl side-chains appended at C7 were prepared to test the effect of the 5-amino group on the biological and physicochemical properties...
8.
Antimalarial activity of 2-(substituted amino)-4,6-bis(trichloromethyl)-1,3,5-triazines and N-(chlorophenyl)-N'-[4-(substituted amino)-6-(trichloromethyl)-1,3,5-triazin-2-yl]guanidines
Werbel L, Elslager E, Hess C, Hutt M
J Med Chem . 1987 Nov; 30(11):1943-8. PMID: 3669002
A series of 2-[[(dialkylamino)alkyl]amino]-4,6-bis(trichloromethyl)-1,3,5-triazines (III) and N-(4-chlorophenyl)-N'-[4-[[(dialkylamino)alkyl]amino]-6- (trichloromethyl)-1,3,5-triazin-2-yl]guanidines (IV) were prepared from 2,4,6-tris(trichloromethyl)-1,3,5-triazine and 2-chloro-4,6-bis(trichloromethyl)-1,3,5-triazine. Compounds of type III showed modest antimalarial activity while XIa with the camoquin side chain...
9.
Chronic recurrent Goodpasture's syndrome
Mehler P, Brunvand M, Hutt M, Anderson R
Am J Med . 1987 Apr; 82(4):833-5. PMID: 3565437
A distinctive case of Goodpasture's syndrome characterized by multiple recurrences occurring over 14 years was observed. Each recurrence followed cessation of prednisone and azathioprine therapy, and reinstitution of this therapy...
10.
New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay
Domagala J, Hanna L, Heifetz C, Hutt M, Mich T, Sanchez J, et al.
J Med Chem . 1986 Mar; 29(3):394-404. PMID: 3005575
A series of 60 newly synthesized and known quinolone antibacterials, including quinoline- and 1,8-naphthyridine-3-carboxylic acids, pyrido[2,3-d]pyrimidine-6-carboxylic acids, and some monocyclic 4-pyridone-3-carboxylic acids, were tested and compared in a newly established,...