M Orzaez
Overview
Explore the profile of M Orzaez including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
68
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Recent Articles
1.
Morais I, Pereira G, Orzaez M, Jorge R, Bincoletto C, Toyama M, et al.
PLoS One
. 2015 Jul;
10(7):e0132569.
PMID: 26193352
Acute renal failure is a common complication caused by Bothrops viper envenomation. In this study, the nefrotoxicity of a main component of B. leucurus venom called L-aminoacid oxidase (LAAO-Bl) was...
2.
Inactivation of Apaf1 reduces the formation of mutant huntingtin-dependent aggregates and cell death
Sancho M, Herrera A, Orzaez M, Perez-Paya E
Neuroscience
. 2014 Jan;
262:83-91.
PMID: 24412373
Polyglutamine expansions in some proteins associated with neurodegenerative diseases, such as Huntington's disease or several ataxias, lead to insoluble aggregates in the cell. These aggregates accumulate through a mechanism that...
3.
Orzaez M, Guevara T, Sancho M, Perez-Paya E
Cell Death Dis
. 2012 Oct;
3:e415.
PMID: 23096116
Inhibitors of the tyrosine kinase activity of epidermal growth factor receptor, as erlotinib, have an established role in treating several cancer types. However, resistance to erlotinib, particularly in breast cancer...
4.
Mondragon L, Orzaez M, Sanclimens G, Moure A, Arminan A, Sepulveda P, et al.
J Med Chem
. 2008 Jan;
51(3):521-9.
PMID: 18197610
The programmed cell death or apoptosis plays both physiological and pathological roles in biology. Anomalous activation of apoptosis has been associated with malignancies. The intrinsic mitochondrial pathway of apoptosis activation...
5.
Malet G, Martin A, Orzaez M, Vicent M, Masip I, Sanclimens G, et al.
Cell Death Differ
. 2005 Dec;
13(9):1523-32.
PMID: 16341125
Apoptosis is a biological process relevant to human disease states that is strongly regulated through protein-protein complex formation. These complexes represent interesting points of chemical intervention for the development of...
6.
Orzaez M, Perez-Paya E, Mingarro I
Protein Sci
. 2000 Jul;
9(6):1246-53.
PMID: 10892817
The monomer-dimer equilibrium of the glycophorin A (GpA) transmembrane (TM) fragment has been used as a model system to investigate the amino acid sequence requirements that permit an appropriate helix-helix...