M N Hylkema
Overview
Explore the profile of M N Hylkema including associated specialties, affiliations and a list of published articles.
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34
Citations
607
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Recent Articles
1.
Heinemann L, Adcock I, Chung K, Lollinga W, Hylkema M, Papi A, et al.
J Inflamm (Lond)
. 2025 Feb;
22(1):7.
PMID: 39934770
COPD has many hallmarks of autoimmune dysfunction. Driving this autoimmune response are self-antigens, such as highly abundant structural proteins and cellular proteins, which can lead to the production of auto-antibodies....
2.
de Hilster R, Sharma P, Jonker M, White E, Gercama E, Roobeek M, et al.
Am J Physiol Lung Cell Mol Physiol
. 2020 Feb;
318(4):L698-L704.
PMID: 32048864
Chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are associated with changes in extracellular matrix (ECM) composition and abundance affecting the mechanical properties...
3.
Spierenburg E, Portengen L, Smit L, Krop E, Hylkema M, Rijkers G, et al.
J Immunol Methods
. 2018 Jul;
460:119-124.
PMID: 30056942
Objective: In epidemiological and clinical studies, whole blood assay (WBA) has been used as a measure to characterize inter-individual differences in the cytokine response of individuals exposed to inflammatory agents,...
4.
Song J, Heijink I, Kistemaker L, Reinders-Luinge M, Kooistra W, Noordhoek J, et al.
Clin Epigenetics
. 2017 Apr;
9:42.
PMID: 28450970
Background: Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed...
5.
Meyer K, Krauss-Etschmann S, Kooistra W, Reinders-Luinge M, Timens W, Kobzik L, et al.
Am J Physiol Lung Cell Mol Physiol
. 2017 Jan;
312(4):L542-L555.
PMID: 28130259
Prenatal smoke exposure is a risk factor for abnormal lung development and increased sex-dependent susceptibility for asthma and chronic obstructive pulmonary disease (COPD). Birth cohort studies show genome-wide DNA methylation...
6.
Spierenburg E, Smit L, Heederik D, Robbe P, Hylkema M, Wouters I
Int Arch Occup Environ Health
. 2015 Mar;
88(8):1165-73.
PMID: 25795169
Objectives: High microbial exposures in farmers and agricultural workers are associated with less atopy. Although it has been speculated that healthy worker survival could be an explanation, this has not...
7.
de Vries M, Heijink I, Gras R, den Boef L, Reinders-Luinge M, Pouwels S, et al.
Am J Physiol Lung Cell Mol Physiol
. 2014 May;
307(3):L240-51.
PMID: 24816488
Exposure to cigarette smoke (CS) is the main risk factor for developing chronic obstructive pulmonary disease and can induce airway epithelial cell damage, innate immune responses, and airway inflammation. We...
8.
Robbe P, Spierenburg E, Draijer C, Brandsma C, Telenga E, van Oosterhout A, et al.
Thorax
. 2014 Feb;
69(7):630-7.
PMID: 24536057
Rationale: A low prevalence of asthma and atopy has been shown in farmers and agricultural workers. However, in these workers, a higher prevalence of respiratory symptoms has been reported, in...
9.
Prins J, Faas M, Melgert B, Huitema S, Timmer A, Hylkema M, et al.
Placenta
. 2012 Mar;
33(5):453-5.
PMID: 22386644
During pregnancy the maternal immune system has to coordinate uterine spiral-artery remodelling, trophoblast invasion, and acceptance of the semi-allogenic fetus simultaneously. As dysregulation of the immune system is associated with...
10.
Brandsma C, Kerstjens H, Geerlings M, Kerkhof M, Hylkema M, Postma D, et al.
Eur Respir J
. 2011 May;
37(5):1289-92.
PMID: 21532021
No abstract available.