M L Ogletree
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Explore the profile of M L Ogletree including associated specialties, affiliations and a list of published articles.
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88
Citations
765
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Recent Articles
11.
GOMOLL A, Grover G, Ogletree M
J Cardiovasc Pharmacol
. 1994 Dec;
24(6):960-8.
PMID: 7898080
The effects of the thromboxane A2 (TXA2)/prostaglandin endoperoxide (TP) receptor antagonist ifetroban (BMS-180291) on infarct size (IS) resulting from coronary occlusion/reperfusion was determined in anesthetized dogs and ferrets. In dogs,...
12.
Grover G, Schumacher W, Ogletree M
J Cardiovasc Pharmacol
. 1994 Sep;
24(3):493-9.
PMID: 7528306
We determined the effect of thromboxane A2 (TXA2) prostaglandin endoperoxide (TP) receptor antagonism, using BMS-180291 or aspirin, on the severity of pacing-induced ischemia in anesthetized dogs. Thromboxane receptor antagonists may...
13.
Vesterqvist O, Sargent C, Grover G, Warrack B, DiDonato G, Ogletree M
Anal Biochem
. 1994 Mar;
217(2):210-9.
PMID: 8203749
We have developed an assay for studying myocardial phospholipase A2 activity by measuring accumulation of lysophospholipids resulting from hydrolysis of the endogenous choline glycerophospholipid pool. This assay was used to...
14.
Schumacher W, Steinbacher T, Heran C, Seiler S, Michel I, Ogletree M
J Pharmacol Exp Ther
. 1993 Dec;
267(3):1237-42.
PMID: 8263785
Different pharmacological approaches to thrombin inhibition were compared for their effects on thrombosis and bleeding time in anesthetized rats. Thrombosis was induced in the carotid artery by transmural vessel injury...
15.
Schumacher W, Heran C, Steinbacher T, Youssef S, Ogletree M
J Cardiovasc Pharmacol
. 1993 Oct;
22(4):526-33.
PMID: 7505353
We determined the effects of aspirin and a novel thromboxane A2/prostaglandin endoperoxide (TP)-receptor antagonist, BMS-180291, on thrombosis and bleeding times in skin and mesenteric arteries. In anesthetized rats, occlusive thrombosis...
16.
GOMOLL A, Ogletree M
Prostaglandins
. 1993 Sep;
46(3):233-42.
PMID: 8234831
The myocardial salvage efficacy of a thromboxane A2/prostaglandin endoperoxide (TP) receptor antagonist has not been previously determined in a ferret model of ischemia and reperfusion. Assessments of the reproducibility of...
17.
Sargent C, Vesterqvist O, Ogletree M, Grover G
J Mol Cell Cardiol
. 1993 Aug;
25(8):905-13.
PMID: 8263961
In isolated Langendorff perfused rat hearts, treatment with exogenous palmitoyl-lysophosphatidylcholine (P-LPC; 3-50 microM) under normoxic conditions, resulted in reduced heart rate (HR), coronary flow (CF) and contractile function. After 30...
18.
Phillipson D, Tymiak A, TUTTLE J, Hartl K, Harper T, Bolgar M, et al.
J Lipid Mediat
. 1993 Jun;
7(2):155-67.
PMID: 8400117
Inhibition of thromboxane receptor radioligand binding to human platelet membranes has been employed as the basis for a radioreceptor assay designed to measure thromboxane receptor binding activity in samples of...
19.
Ogletree M, HARRIS D, Schumacher W, Webb M, Misra R
J Pharmacol Exp Ther
. 1993 Feb;
264(2):570-8.
PMID: 8437108
180,291 1S-(1 alpha, 2 alpha, 3 alpha, 4 alpha)-2-[[3-[4- [(pentylamino)carbonyl]-2-oxazolyl]-7-oxabicyclo[2.2.1]hept- 2- yl]methyl]benzenepropanoic acid (BMS) is a potent and highly selective antagonist of thromboxane A2/prostaglandin endoperoxide (TP) receptors. In human platelet-rich...
20.
Schumacher W, Steinbacher T, Youssef S, Ogletree M
Prostaglandins
. 1992 Nov;
44(5):389-97.
PMID: 1301074
The effects of the novel TxA2/prostaglandin endoperoxide (TP) receptor antagonist BMS 180,291 on platelet reactivity was determined ex vivo in conscious African green monkeys. Platelet aggregation responses to U-46,619 were...