M L Cuzner
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Explore the profile of M L Cuzner including associated specialties, affiliations and a list of published articles.
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119
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2579
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Recent Articles
11.
Petzold A, Eikelenboom M, Gveric D, Keir G, Chapman M, Lazeron R, et al.
Brain
. 2002 Jun;
125(Pt 7):1462-73.
PMID: 12076997
Disease progression in multiple sclerosis occurs within the interface of glial activation and gliosis. This study aimed to investigate the relationship between biomarkers of different glial cell responses: (i) to...
12.
Copelman C, Diemel L, Gveric D, Gregson N, Cuzner M
J Neurosci Res
. 2001 Dec;
66(6):1173-8.
PMID: 11746450
An increased level of myelin basic protein (MBP) degradation peptide 80-89, representative of myelin breakdown, is detected in myelinating foetal rat brain aggregate cultures supplemented with peritoneal macrophages at a...
13.
Gveric D, Hanemaaijer R, Newcombe J, van Lent N, Sier C, Cuzner M
Brain
. 2001 Sep;
124(Pt 10):1978-88.
PMID: 11571216
Components of the plasminogen activator (PA) and matrix metalloprotease (MMP) cascade have been characterized in multiple sclerosis lesions by immunohistochemistry, enzyme-linked immunosorbent assay and enzyme activity assays in order to...
14.
Ahmed Z, Gveric D, Pryce G, Baker D, Leonard J, Cuzner M, et al.
Am J Pathol
. 2001 Jun;
158(6):2127-38.
PMID: 11395390
Lewis rats, on recovery from monophasic clinical experimental allergic encephalomyelitis (EAE), can be induced to develop repeated paralytic relapses with a graded reduction in clinical severity following intraperitoneal administration of...
15.
Bajramovic J, Plomp A, Goes A, Koevoets C, Newcombe J, Cuzner M, et al.
J Immunol
. 2001 Feb;
164(8):4359-66.
PMID: 10754336
In the development of multiple sclerosis (MS), (re)activation of infiltrating T cells by myelin-derived Ags is considered to be a crucial step. Previously, alpha B-crystallin has been shown to be...
16.
Banati R, Newcombe J, Gunn R, Cagnin A, Turkheimer F, Heppner F, et al.
Brain
. 2000 Oct;
123 ( Pt 11):2321-37.
PMID: 11050032
This study identifies by microautoradiography activated microglia/macrophages as the main cell type expressing the peripheral benzodiazepine binding site (PBBS) at sites of active CNS pathology. Quantitative measurements of PBBS expression...
17.
Black J, Dib-Hajj S, Baker D, Newcombe J, Cuzner M, Waxman S
Proc Natl Acad Sci U S A
. 2000 Oct;
97(21):11598-602.
PMID: 11027357
Clinical abnormalities in multiple sclerosis (MS) have classically been considered to be caused by demyelination and/or axonal degeneration; the possibility of molecular changes in neurons, such as the deployment of...
18.
Simpson J, Rezaie P, Newcombe J, Cuzner M, Male D, Woodroofe M
J Neuroimmunol
. 2000 Jul;
108(1-2):192-200.
PMID: 10900353
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) characterised by perivascular inflammatory cell infiltrates and plaques of demyelination. Chemokines have been shown to play...
19.
Hayes G, Fox R, Cuzner M, Griffin G
Neurosci Lett
. 2000 Jun;
287(2):146-50.
PMID: 10854733
One difficulty in generating in vitro models of neuropathogenesis lies in maintaining stable proportions of primary neurons within a mixed brain cell population. Rotation-mediated fetal brain aggregate culture has been...
20.
Simpson J, Newcombe J, Cuzner M, Woodroofe M
Neuropathol Appl Neurobiol
. 2000 Jun;
26(2):133-42.
PMID: 10840276
The recruitment of leucocytes to sites of inflammation is an important feature of multiple sclerosis (MS) pathology. Chemokines are involved in the activation and specific directional migration of monocytes and...