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M Kevin Brown

Explore the profile of M Kevin Brown including associated specialties, affiliations and a list of published articles. Areas
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Articles 83
Citations 1202
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Recent Articles
1.
Liu Y, Tranin S, Chang Y, Piper E, Fessard T, Van Hoveln R, et al.
J Am Chem Soc . 2025 Feb; 147(8):6318-6325. PMID: 39962893
Rigid bicyclic hydrocarbons have emerged as important building blocks in the drug discovery industry. Despite progress in this general area, bicyclo[2.1.0]pentanes (housanes) are an understudied class of molecules. Herein we...
2.
Adak S, Hazra P, Fox C, Brown M
Angew Chem Int Ed Engl . 2024 Nov; 64(4):e202416215. PMID: 39508634
A strategy for the photosensitized [2+2]-cycloaddition between styrenyl dihaloboranes and unactivated allylamines to access cyclobutylboronates with control of stereochemistry and regiochemistry is presented. The success of the reaction relies on...
3.
Trammel G, Kerlin A, Zachau C, Brown M
Synlett . 2024 Oct; 34(18):2197-2199. PMID: 39464301
A synthesis of (±)-phyltetralin is reported. Notable features of the synthesis include a diastereoselective Cu/Pd-catalyzed arylboration reaction and a Matteson homologation.
4.
Paul S, Brown M
Angew Chem Int Ed Engl . 2024 Aug; 63(37):e202408432. PMID: 39092618
A strategy for transition metal-free cross-coupling of alkyl nitroso-carbamates and boronic acids is reported. The N-nitroso carbamates are easily prepared from the corresponding amine in two simple steps. This method...
5.
Lyu M, Jacobo S, Brown M
J Am Chem Soc . 2024 Jul; 146(28):18866-18872. PMID: 38967118
C-Glycosides are important structures that are common to natural products and pharmaceutical agents. Established methods for their synthesis involve the reaction of an activated anomeric carbon. In this study, we...
6.
Posz J, Sharma N, Royalty P, Liu Y, Salome C, Fessard T, et al.
J Am Chem Soc . 2024 Mar; 146(14):10142-10149. PMID: 38536870
Saturated bicyclic compounds make up a valuable class of building blocks in the development of agrochemicals and pharmaceuticals. Here, we present the synthesis of borylated bicyclo[2.1.1]hexanes via crossed [2 +...
7.
Adak S, Braley S, Brown M
Org Lett . 2024 Jan; 26(1):401-405. PMID: 38169485
The saturation of aromatic scaffolds is valuable for the synthesis of complex rings. Herein, we demonstrate a process for photochemical dearomative reduction of quinolines. The process involves capture of a...
8.
Lyu M, Morais G, Chen S, Brown M
J Am Chem Soc . 2023 Dec; 145(50):27254-27261. PMID: 38078874
Alkene borylfunctionalization reactions have emerged as useful methods for chemical synthesis. While much progress has been made on 1,2-borylamination reactions, the related 1,1- and 1,3-borylaminations have not been reported. Herein,...
9.
Chang Y, Salome C, Fessard T, Brown M
Angew Chem Int Ed Engl . 2023 Nov; 62(51):e202314700. PMID: 37963812
Rigid bicycles are becoming more popular in the pharmaceutical industry because they allow for expansion to new and unique chemical spaces. This work describes a new strategy to construct 2-azanorbornanes,...
10.
Liu Y, Brown M
J Am Chem Soc . 2023 Nov; 145(46):25061-25067. PMID: 37939224
A strategy to achieve photosensitized [2 + 2] cycloadditions by means of temporary ring constraint is reported. Specifically, a dioxaborole is prepared that undergoes [2 + 2] cycloadditions with a...