M J Warren
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Explore the profile of M J Warren including associated specialties, affiliations and a list of published articles.
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77
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1439
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Recent Articles
1.
Azim N, Deery E, Warren M, Wolfenden B, Erskine P, Cooper J, et al.
Acta Crystallogr D Biol Crystallogr
. 2014 Mar;
70(Pt 3):744-51.
PMID: 24598743
The enzyme porphobilinogen deaminase (PBGD; hydroxymethylbilane synthase; EC 2.5.1.61) catalyses an early step of the tetrapyrrole-biosynthesis pathway in which four molecules of the monopyrrole porphobilinogen are condensed to form a...
2.
Azim N, Deery E, Warren M, Erskine P, Cooper J, Wood S, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2013 Aug;
69(Pt 8):906-8.
PMID: 23908040
The enzyme porphobilinogen deaminase (PBGD; hydroxymethylbilane synthase; EC 2.5.1.61) catalyses an early step of the tetrapyrrole-biosynthesis pathway in which four molecules of the monopyrrole porphobilinogen are condensed to form a...
3.
Power P, Ku S, Rutter K, Warren M, Limnios E, Tapsall J, et al.
Infect Immun
. 2007 Feb;
75(6):3202-4.
PMID: 17296763
The Neisseria gonorrhoeae pglA gene has two alleles, one of which is phase variable. A previous study reported that all disseminated gonococcal infection (DGI) isolates contained the phase-variable allele and...
4.
Erskine P, Coates L, Newbold R, BRINDLEY A, Stauffer F, Beaven G, et al.
Acta Crystallogr D Biol Crystallogr
. 2005 Sep;
61(Pt 9):1222-6.
PMID: 16131755
The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase (ALAD) from yeast complexed with the competitive inhibitor 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The structure...
5.
Heldt D, Lawrence A, Lindenmeyer M, Deery E, Heathcote P, Rigby S, et al.
Biochem Soc Trans
. 2005 Jul;
33(Pt 4):815-9.
PMID: 16042605
The aerobic biosynthetic pathway for vitamin B12 (cobalamin) biosynthesis is reviewed. Particular attention is focused on the ring contraction process, whereby an integral carbon atom of the tetrapyrrole-derived macrocycle is...
6.
Frank S, BRINDLEY A, Deery E, Heathcote P, Lawrence A, Leech H, et al.
Biochem Soc Trans
. 2005 Jul;
33(Pt 4):811-4.
PMID: 16042604
The anaerobic biosynthesis of vitamin B12 is slowly being unravelled. Recent work has shown that the first committed step along the anaerobic route involves the sirohydrochlorin (chelation of cobalt into...
7.
Leech H, Heathcote P, Warren M
Biochem Soc Trans
. 2002 Aug;
30(4):610-3.
PMID: 12196147
One of the four operons required for cobalamin biosynthesis in Bacillus megaterium is also associated with sirohaem synthesis, and contains three genes, sirA, sirB and sirC. By undertaking functional complementation...
8.
Schubert H, Raux E, Matthews M, Phillips J, Wilson K, Hill C, et al.
Biochem Soc Trans
. 2002 Aug;
30(4):595-600.
PMID: 12196144
All tetrapyrroles are synthesized through a branched pathway, and although each tetrapyrrole receives unique modifications around the ring periphery, they all share the unifying feature of a central metal ion....
9.
Martens J, Barg H, Warren M, Jahn D
Appl Microbiol Biotechnol
. 2002 Apr;
58(3):275-85.
PMID: 11935176
One of the most alluring and fascinating molecules in the world of science and medicine is vitamin B12 (cobalamin), which was originally discovered as the anti pernicious anemia factor and...
10.
Erskine P, Newbold R, BRINDLEY A, Wood S, Shoolingin-Jordan P, Warren M, et al.
J Mol Biol
. 2001 Sep;
312(1):133-41.
PMID: 11545591
The structures of 5-aminolaevulinic acid dehydratase (ALAD) complexed with substrate (5-aminolaevulinic acid) and three inhibitors: laevulinic acid, succinylacetone and 4-keto-5-aminolaevulinic acid, have been solved at high resolution. The ligands all...