M J Murphy Jr
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Explore the profile of M J Murphy Jr including associated specialties, affiliations and a list of published articles.
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92
Citations
302
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Recent Articles
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Cardier J, Murphy Jr M
Stem Cells
. 1997 Jan;
15(6):437-42.
PMID: 9402656
The growth-promoting activities of interleukin 6 (IL-6) in combination with early-acting hematopoietic factors, i.e., stem cell factor (SCF) and interleukin-1 alpha (IL-1 alpha), on primitive hematopoietic and megakaryocyte progenitors (high...
3.
Cardier J, Murphy Jr M
Stem Cells
. 1997 Jan;
15(4):286-90.
PMID: 9253112
In this study we have explored the effect of recombinant human erythropoietin (EPO) and recombinant murine GM-CSF on megakaryocyte progenitors (colony forming units-megakaryocyte [CFU-Mk]) using a serum-free fibrin clot assay...
4.
Ramsfjell V, Borge O, Veiby O, Cardier J, Murphy Jr M, Lyman S, et al.
Blood
. 1996 Dec;
88(12):4481-92.
PMID: 8977240
Thrombopoietin (Tpo), the ligand for c-mpl, has been shown to be the principal regulator of megakaryocytopoiesis and platelet production. The ability of Tpo to potently stimulate the growth of committed...
5.
Borge O, Ramsfjell V, Veiby O, Murphy Jr M, Lok S, Jacobsen S
Blood
. 1996 Oct;
88(8):2859-70.
PMID: 8874182
The recently cloned c-mpl ligand, thrombopoietin (Tpo), has been extensively characterized with regard to its ability to stimulate the growth, development, and ploidy of megakaryocyte progenitor cells and platelet production...
6.
Jacobsen S, Borge O, Ramsfjell V, Cui L, Cardier J, Veiby O, et al.
Stem Cells
. 1996 Jan;
14 Suppl 1:173-80.
PMID: 11012218
Thrombopoietin (TPO), the ligand for c-mpl, has recently been demonstrated to be the primary regulator of megakaryocytopoiesis and platelet production. In addition, several studies have demonstrated that c-mpl is expressed...
7.
Cardier J, Foster D, Lok S, Jacobsen S, Murphy Jr M
Stem Cells
. 1996 Jan;
14 Suppl 1:163-72.
PMID: 11012217
Megakaryocytopoiesis is a complex network regulated by different megakaryocyte (MK)-stimulating factors (i.e., thrombopoietin [TPO], stem cell factor [SCF], interleukin 3 [IL-3], IL-6, IL-11 and GM-CSF). Although all of these factors...
8.
Murphy Jr M, Fushimi F, Parchment R
Invest New Drugs
. 1996 Jan;
13(4):303-14.
PMID: 8824348
Human colony forming units (CFUs) from both malignant and hematopoietic tissues can be assayed in vitro in microcapillary cultures, an alternative cloning system to the Petri dish methodology. For technical...
9.
Cheng T, Li C, Cardier J, Wang Y, Dempsey J, Mogle M, et al.
Leukemia
. 1995 Jul;
9(7):1257-63.
PMID: 7543177
We have characterized HIMeg-1, a subclone of the promegakaryoblastic cell line HIMeg, in terms of its capability of proliferation and differentiation when it is exposed to various agents. We observed...
10.
Gupta S, Carlin J, Pyati P, Dai W, Pfefferkorn E, Murphy Jr M
Infect Immun
. 1994 Jun;
62(6):2277-84.
PMID: 8188349
Studies were carried out to evaluate the proposed role of indoleamine 2,3-dioxygenase (INDO) induction in the antimicrobial and antiproliferative effects of gamma interferon (IFN-gamma) in human fibroblasts. The INDO cDNA...