M J De Long
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Explore the profile of M J De Long including associated specialties, affiliations and a list of published articles.
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8
Citations
274
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Recent Articles
1.
Enhanced NAD(P)H:quinone reductase activity prevents glutamate toxicity produced by oxidative stress
Murphy T, De Long M, Coyle J
J Neurochem
. 1991 Mar;
56(3):990-5.
PMID: 1704427
Glutamate toxicity in the N18-RE-105 neuronal cell line results from the inhibition of high-affinity cystine uptake, which leads to a depletion of glutathione and the accumulation of oxidants. Production of...
2.
Talalay P, De Long M, Prochaska H
Proc Natl Acad Sci U S A
. 1988 Nov;
85(21):8261-5.
PMID: 3141925
Carcinogenesis is blocked by an extraordinary variety of agents belonging to many different classes--e.g., phenolic antioxidants, azo dyes, polycyclic aromatics, flavonoids, coumarins, cinnamates, indoles, isothiocyanates, 1,2-dithiol-3-thiones, and thiocarbamates. The only...
3.
De Long M, Santamaria A, Talalay P
Carcinogenesis
. 1987 Oct;
8(10):1549-53.
PMID: 2820604
NAD(P)H:Quinone oxidoreductase (QR) is a widely-distributed enzyme that promotes obligatory two-electron reductions of quinones and thereby protects cells against the cytotoxicity of quinones and their metabolic precursors. QR is induced...
4.
De Long M, Dolan P, Santamaria A, Bueding E
Carcinogenesis
. 1986 Jun;
7(6):977-80.
PMID: 3708758
The 1,2-dithiol-3-thiones are a class of five-membered cyclic sulfur compounds which have chemotherapeutic and chemoprotective properties. The parent 1,2-dithiol-3-thione nucleus and a series of six substituted analogs all induced NAD(P)H:...
5.
De Long M, Prochaska H, Talalay P
Proc Natl Acad Sci U S A
. 1986 Feb;
83(3):787-91.
PMID: 3080750
Exposure of murine hepatoma (Hepa 1c1c7) cells to a variety of chemical agents known to protect animals against the neoplastic, mutagenic, and other toxic effects of chemical carcinogens results in...
6.
Prochaska H, De Long M, Talalay P
Proc Natl Acad Sci U S A
. 1985 Dec;
82(23):8232-6.
PMID: 3934671
Induction of detoxification enzymes is a major mechanism whereby a wide variety of chemical agents protect rodents against neoplastic, mutagenic, and other toxicities of carcinogens. The enzyme NAD(P)H:(quinone acceptor) oxidoreductase...
7.
Prochaska H, Bregman H, De Long M, Talalay P
Biochem Pharmacol
. 1985 Nov;
34(21):3909-14.
PMID: 4062966
Protection by 2(3)-tert-butyl-4-hydroxyanisole (BHA) and related phenols against chemical carcinogens, mutagens and other toxins has been attributed to the elevation of tissue levels of non-oxygenative detoxification enzymes. To analyze the...
8.
De Long M, Prochaska H, Talalay P
Cancer Res
. 1985 Feb;
45(2):546-51.
PMID: 3917849
Some of the anticarcinogenic effects of 2(3)-tert-butyl-4-hydroxyanisole (BHA) are attributable to the induction of detoxifying enzymes in the liver and peripheral tissues. This study was designed to determine if the...