M J Churcher
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Explore the profile of M J Churcher including associated specialties, affiliations and a list of published articles.
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11
Citations
310
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Recent Articles
1.
Turner I, Norman C, Churcher M, Newman A
Biochem Soc Trans
. 2004 Oct;
32(Pt 6):928-31.
PMID: 15506927
Most protein-coding genes in eukaryotes are interrupted by non-coding intervening sequences (introns), which must be precisely removed from primary gene transcripts (pre-mRNAs) before translation of the message into protein. Intron...
2.
Moriyama K, Negishi K, Briggs M, Smith C, Hill F, Churcher M, et al.
Nucleic Acids Res
. 1998 Jun;
26(9):2105-11.
PMID: 9547267
The synthesis and enzymatic incorporation into RNA of the hydrogen bond degenerate nucleoside analogue 6-(beta-d-ribofuranosyl)-3, 4-dihydro-8H-pyrimido[4,5-c]-[1,2]oxazin-7-one (P) is described. The 5'-triphosphate of this analogue is readily incorporated by T3, T7...
3.
Keen N, Churcher M, Karn J
EMBO J
. 1997 Oct;
16(17):5260-72.
PMID: 9311986
The HIV-1 trans-activator protein, Tat, is a potent activator of transcriptional elongation. Tat is recruited to the elongating RNA polymerase during its transit through the trans-activation response region (TAR) because...
4.
Rittner K, Churcher M, Gait M, Karn J
J Mol Biol
. 1995 May;
248(3):562-80.
PMID: 7752225
The effects of mutations in human immunodeficiency virus type-1 (HIV-1) long terminal repeat on initiation and on Tat-mediated trans-activation were studied using cell-free transcription assays. All the elements that are...
5.
Churcher M, Lowe A, Gait M, Karn J
Proc Natl Acad Sci U S A
. 1995 Mar;
92(6):2408-12.
PMID: 7892280
The human immunodeficiency virus type 1 (HIV-1) trans-activator protein, Tat, specifically stimulates transcription from the viral long terminal repeat. Tat binds to an RNA stem-loop structure encoded by the trans-activation...
6.
Graeble M, Churcher M, Lowe A, Gait M, Karn J
Proc Natl Acad Sci U S A
. 1993 Jul;
90(13):6184-8.
PMID: 8327498
The human immunodeficiency virus type 1 transactivator protein, tat, specifically stimulates transcription from the viral long terminal repeat. We used cell-free transcription systems to test whether tat can stimulate transcriptional...
7.
Churcher M, Lamont C, Hamy F, Dingwall C, Green S, Lowe A, et al.
J Mol Biol
. 1993 Mar;
230(1):90-110.
PMID: 8450553
The binding site for tat protein on TAR RNA has been defined in quantitative terms using an extensive series of mutations. The relative dissociation constants for the mutant TAR RNAs...
8.
Cann A, Churcher M, Boyd M, OBrien W, Zhao J, ZACK J, et al.
J Virol
. 1992 Jan;
66(1):305-9.
PMID: 1727490
Different isolates of human immunodeficiency virus type 1 (HIV-1) vary in the cell tropisms they display, i.e., the range of cell types in which they are able to establish a...
9.
McLean C, Churcher M, Meinke J, Smith G, Higgins G, Stanley M, et al.
J Clin Pathol
. 1990 Jun;
43(6):488-92.
PMID: 2166093
A monoclonal antibody was raised against the major capsid protein L1 of human papillomavirus type 16, using a recombinant vaccinia virus that expresses the L1 protein, as a target for...
10.
Browne H, Churcher M, Stanley M, Smith G, Minson A
J Gen Virol
. 1988 Jun;
69 ( Pt 6):1263-73.
PMID: 2838573
The L1 open reading frame of human papillomavirus type 16 (HPV16) has been expressed in vaccinia virus under the control of both the 7.5K early and late promoter, and the...