M Gaino
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Explore the profile of M Gaino including associated specialties, affiliations and a list of published articles.
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6
Citations
13
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Recent Articles
1.
Inoue H, Konda M, Hashiyama T, Otsuka H, Watanabe A, Gaino M, et al.
Chem Pharm Bull (Tokyo)
. 1997 Jun;
45(6):1008-26.
PMID: 9214707
2,3-Dihydro-1,5-benzothiazepin-4(5H)-ones substituted with an alkyl, alkoxy, alkylthio, hydroxy, or amino group on the fused benzene ring of the 1,5-benzothiazepine skeleton were synthesized and their vasodilating, antihypertensive, and platelet aggregation-inhibitory activities...
2.
Inoue H, Nakamura S, Otsuka H, Gaino M, Harada T, Matsuki K, et al.
Chem Pharm Bull (Tokyo)
. 1994 Jan;
42(1):167-72.
PMID: 8124760
The metabolites of clentiazem in the urine or bile of rats and dogs were investigated. Fifteen basic, 6 acidic, 2 neutral and 4 conjugated metabolites were isolated. In the present...
3.
Inoue H, Konda M, Hashiyama T, Otsuka H, Takahashi K, Gaino M, et al.
J Med Chem
. 1991 Feb;
34(2):675-87.
PMID: 1995892
In an attempt to improve the effectiveness and duration of the action of diltiazem (1), a 1,5-benzothiazepine calcium channel blocker, its derivatives (2) with halogen substituents on the fused benzene...
4.
Narita H, Gaino M, Suzuki T, Kurosawa H, Inoue H, Nagao T
Chem Pharm Bull (Tokyo)
. 1990 Feb;
38(2):407-10.
PMID: 2337956
Since azido derivatives of 1,5-benzothiazepine Ca antagonist available for photoaffinity labeling are required for further studies of voltage-sensitive Ca channels, we synthesized 3-(p-azidobenzoyloxydeacetyl)- and 3-(4-azidobutyryloxydeacetyl)-diltiazem, and studied their pharmacological properties....
5.
Sugawara Y, Ohashi M, Nakamura S, Usuki S, Suzuki T, Ito Y, et al.
J Pharmacobiodyn
. 1988 Apr;
11(4):211-23.
PMID: 3411439
The metabolites of diltiazem in the urine of rats, dogs and man and rat bile were investigated. New metabolites including six acidic metabolites (A1-A6) and four basic metabolites (M9, MB,...
6.
Ikezaki M, Umino N, Gaino M, Aoe K, Iwakuma T
Yakugaku Zasshi
. 1986 Jan;
106(1):80-9.
PMID: 3701602
No abstract available.