M Fernanda Lara
Overview
Explore the profile of M Fernanda Lara including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
298
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Recent Articles
1.
Costa C, Santos M, Segrelles C, Duenas M, Lara M, Agirre X, et al.
Sci Rep
. 2012 Nov;
2:828.
PMID: 23145321
The specific ablation of Rb1 gene in stratified epithelia (Rb(F/F);K14cre) promotes proliferation and altered differentiation but is insufficient to produce spontaneous tumors. The pRb relative, p107, compensates some of the...
2.
Moral M, Segrelles C, Lara M, Martinez-Cruz A, Lorz C, Santos M, et al.
Cancer Res
. 2009 Jan;
69(3):1099-108.
PMID: 19176372
Head and neck squamous cell carcinoma (HNSCC) is a common human neoplasia with poor prognosis and survival that frequently displays Akt overactivation. Here we show that mice displaying constitutive Akt...
3.
Santos M, Ruiz S, Lara M, Segrelles C, Moral M, Martinez-Cruz A, et al.
Mol Carcinog
. 2008 Feb;
47(11):815-21.
PMID: 18300254
Functional inactivation of the pRb-dependent pathway is a general feature of human cancer. However, only a reduced spectrum of tumors displays inactivation of the Rb gene. This can be attributed,...
4.
Martinez-Cruz A, Santos M, Lara M, Segrelles C, Ruiz S, Moral M, et al.
Cancer Res
. 2008 Feb;
68(3):683-92.
PMID: 18245467
Squamous cell carcinomas (SCC) represent the most aggressive type of nonmelanoma skin cancer. Although little is known about the causal alterations of SCCs, in organ-transplanted patients the E7 and E6...
5.
Segrelles C, Lu J, Hammann B, Santos M, Moral M, Cascallana J, et al.
Cancer Res
. 2007 Nov;
67(22):10879-88.
PMID: 18006833
Aberrant activation of the phosphoinositide-3-kinase (PI3K)/PTEN/Akt pathway, leading to increased proliferation and decreased apoptosis, has been implicated in several human pathologies including cancer. Our previous data have shown that Akt-mediated...
6.
Segrelles C, Moral M, Lorz C, Santos M, Lu J, Cascallana J, et al.
Mol Biol Cell
. 2007 Oct;
19(1):137-49.
PMID: 17959825
Aberrant activation of the Akt pathway has been implicated in several human pathologies including cancer. However, current knowledge on the involvement of Akt signaling in development is limited. Previous data...
7.
Lara M, Garcia-Escudero R, Ruiz S, Santos M, Moral M, Martinez-Cruz A, et al.
Mol Carcinog
. 2007 Oct;
47(3):209-21.
PMID: 17932948
The epidermal-specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in vitro. These differences in phenotype are more severe...
8.
Lara M, Santos M, Ruiz S, Segrelles C, Moral M, Martinez-Cruz A, et al.
Mol Carcinog
. 2007 Oct;
47(2):105-13.
PMID: 17932945
The specific deletion of Rb gene in epidermis leads to altered proliferation and differentiation, but not to the development of spontaneous tumors. Our previous data have demonstrated the existence of...
9.
Ruiz S, Santos M, Lara M, Segrelles C, Ballestin C, Paramio J
Cancer Res
. 2005 Nov;
65(21):9678-86.
PMID: 16266987
The mouse skin carcinogenesis represents one of the best models for the understanding of malignant transformation, including the multistage nature of tumor development. The retinoblastoma gene product (pRb) plays a...
10.
Segrelles C, Moral M, Lara M, Ruiz S, Santos M, Leis H, et al.
Oncogene
. 2005 Oct;
25(8):1174-85.
PMID: 16247457
The PI3K/PTEN/Akt signaling pathway has emerged in recent years as a main player in human cancers, increasing proliferation and decreasing apoptosis of transformed cells, and thus becoming a potential target...