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M E Schiphorst

Explore the profile of M E Schiphorst including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 146
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Recent Articles
1.
Lankhof H, Damas C, Schiphorst M, Ijsseldijk M, Bracke M, Furlan M, et al.
Thromb Haemost . 1999 Jul; 81(6):976-83. PMID: 10404778
Type 2A von Willebrand Disease (vWD) is characterized by the absence of high molecular weight von Willebrand factor (VWF) multimers in plasma which is caused by enhanced extracellular proteolysis or...
2.
van der Plas R, Schiphorst M, Huizinga E, Hene R, Verdonck L, Sixma J, et al.
Blood . 1999 May; 93(11):3798-802. PMID: 10339486
Thrombotic thrombocytopenic purpura (TTP) after bone marrow transplantation (BMT) differs from classic TTP in its clinical course and therapy. A characteristic of classic TTP is the inhibition of a plasma...
3.
Lankhof H, Damas C, Schiphorst M, Ijsseldijk M, Bracke M, Furlan M, et al.
Thromb Haemost . 1997 May; 77(5):1008-13. PMID: 9184419
von Willebrand factor (vWF) is a complex multimeric plasma glycoprotein, that plays a critical role in the mediation of platelet adhesion to the damaged vascular wall, and functions as a...
4.
Lankhof H, Damas C, Schiphorst M, Ijsseldijk M, Bracke M, Sixma J, et al.
Blood . 1997 Apr; 89(8):2766-72. PMID: 9108394
Type 2B von Willebrand disease (vWD) is characterized by the absence of the very high molecular weight von Willebrand factor (vWF) multimers from plasma, which is caused by spontaneous binding...
5.
Lankhof H, van Hoeij M, Schiphorst M, Bracke M, Wu Y, Ijsseldijk M, et al.
Thromb Haemost . 1996 Jun; 75(6):950-8. PMID: 8822592
von Willebrand factor (vWF) mediates platelet adhesion at sites of vascular damage. It acts as a bridge between receptors on platelets and collagens present in the connective tissue. Two collagen...
6.
Koppelman S, van Hoeij M, Vink T, Lankhof H, Schiphorst M, Damas C, et al.
Blood . 1996 Mar; 87(6):2292-300. PMID: 8630390
The interaction of factor VIII with von Willebrand factor (vWF) was investigated on a quantitative and qualitative level. Binding characteristics were determined using a solid phase binding assay and protection...
7.
van Zanten G, Connolly T, Schiphorst M, de Graaf S, Slootweg P, Sixma J
Arterioscler Thromb Vasc Biol . 1995 Sep; 15(9):1424-31. PMID: 7670958
Salivary glands of the leech Haementeria officinalis contain a protein, leech antiplatelet protein (LAPP). This protein was cloned and expressed in yeast and blocks collagen-mediated platelet aggregation and the adhesion...
8.
Lankhof H, Wu Y, Vink T, Schiphorst M, Zerwes H, de Groot P, et al.
Blood . 1995 Aug; 86(3):1035-42. PMID: 7620157
To assess the relative importance of the glycoprotein (GP) Ib binding domain and the RGDS binding site in platelet adhesion to isolated von Willebrand factor (vWF) and to collagen preincubated...
9.
Sixma J, Schiphorst M, Verweij C, Pannekoek H
Eur J Biochem . 1991 Mar; 196(2):369-75. PMID: 1901037
In order to study the functional importance of the collagen, heparin and glycoprotein-Ib-binding domain, we deleted the A1 domain of von Willebrand factor (vWF), corresponding to residues 478-716, by oligonucleotide-directed...
10.
Houdijk W, Schiphorst M, Sixma J
Blood . 1986 May; 67(5):1498-503. PMID: 3486014
With the use of monoclonal antibodies that inhibit the ristocetin-induced binding of von Willebrand factor (VWF) to platelets and the binding to collagen, we have previously identified two distinct tryptic...