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M Denise Dearing

Explore the profile of M Denise Dearing including associated specialties, affiliations and a list of published articles. Areas
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Articles 107
Citations 1710
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Recent Articles
1.
Klure D, Greenhalgh R, Orr T, Shapiro M, Dearing M
Science . 2025 Jan; 387(6730):156-162. PMID: 39787210
How mammalian herbivores evolve to feed on chemically defended plants remains poorly understood. In this study, we investigated the adaptation of two species of woodrats ( and ) to creosote...
2.
Stapleton T, Lindsey L, Sundar H, Dearing M
Anim Microbiome . 2024 Jul; 6(1):43. PMID: 39080711
Gut microbiota are intrinsic to an herbivorous lifestyle, but very little is known about how plant secondary compounds (PSCs), which are often toxic, influence these symbiotic partners. Here we interrogated...
3.
Greenhalgh R, Klure D, Orr T, Armstrong N, Shapiro M, Dearing M
Comp Biochem Physiol C Toxicol Pharmacol . 2024 Mar; 280:109870. PMID: 38428625
Liver biotransformation enzymes have long been thought to enable animals to feed on diets rich in xenobiotic compounds. However, despite decades of pharmacological research in humans and rodents, little is...
4.
Doolin M, Dearing M
J Infect Dis . 2023 Nov; 229(3):908-917. PMID: 38036425
Background: Parasitic infections challenge vertebrate health worldwide, and off-target effects of antiparasitic treatments may be an additional obstacle to recovery. However, there have been few investigations of the effects of...
5.
Weinstein S, Stephens W, Greenhalgh R, Round J, Dearing M
Symbiosis . 2023 Nov; 87(1):45-58. PMID: 37915425
Fungi are often overlooked in microbiome research and, as a result, little is known about the mammalian mycobiome. Although frequently detected in vertebrate guts and known to contribute to digestion...
6.
Klure D, Dearing M
FEMS Microbiol Ecol . 2023 Oct; 99(11). PMID: 37838471
Gut microbes provide essential services to their host and shifts in their composition can impact host fitness. However, despite advances in our understanding of how microbes are assembled in the...
7.
Dearing M, Orr T, Klure D, Greenhalgh R, Weinstein S, Stapleton T, et al.
Funct Ecol . 2023 Sep; 36(8):2119-2131. PMID: 37727272
Little is known about the tolerances of mammalian herbivores to plant specialized metabolites across landscapes.We investigated the tolerances of two species of herbivorous woodrats, (desert woodrat) and (Bryant's woodrat) to...
8.
Klure D, Greenhalgh R, Dearing M
Mamm Res . 2023 Mar; 67(4):499-509. PMID: 36968646
High-throughput sequencing approaches have revolutionized how we study animal diets by enabling the detection of dietary components from the metabarcoding of DNA in excrement. Mitochondrial cytochrome oxidase C subunit I...
9.
Klure D, Greenhalgh R, Parchman T, Matocq M, Galland L, Shapiro M, et al.
Evolution . 2023 Jan; 77(4):959-970. PMID: 36715204
Hybridization is a common process that has broadly impacted the evolution of multicellular eukaryotes; however, how ecological factors influence this process remains poorly understood. Here, we report the findings of...
10.
Dearing M, Kaltenpoth M, Gershenzon J
Symbiosis . 2022 Sep; 87(1):59-66. PMID: 36164313
Plant toxins constitute an effective defense against herbivorous animals. However, many herbivores have evolved adaptations to cope with dietary toxins through detoxification, excretion, sequestration, target site insensitivity and/or via behavioral...