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M Danilo Boada

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Citations 219
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Recent Articles
1.
Gutierrez S, Parker R, Zhang M, Santi M, Ye Y, Boada M
Mol Pain . 2025 Feb; :17448069251323666. PMID: 39945101
Preclinical studies addressing the peripheral effects of cancer perineural invasion report severe neuronal availability and excitability changes. Oral cell squamous cell carcinoma perineural invasion (MOC2-PNI) shows similar effects, modulating the...
2.
Gutierrez S, Parker R, Parker R, Zhang M, Santi M, Ye Y, et al.
Mol Pain . 2025 Feb; 21:17448069251314738. PMID: 39921540
Patients with cancer perineural invasion (PNI) report greater spontaneous pain and mechanical allodynia. Here, we examine the impact of the disease on the peripheral sensory system, the excitability changes induced...
3.
Gutierrez S, Boada M
Neuropeptides . 2024 Nov; 109:102479. PMID: 39591909
Several data indicate that Substance P (SP) neurokinin type 1 receptor (NK1R) is at the center of the interaction between cancer cells and peripheral sensory neurons. Selecting the appropriate cancer...
4.
Boada M, Gutierrez S
Mol Pain . 2024 Aug; 20:17448069241276378. PMID: 39107056
In the mammalian somatosensory system, polymodality is defined as the competence of some neurons to respond to multiple forms of energy (e.g., mechanical and thermal). This ability is thought to...
5.
Boada M, Gutierrez S, Eisenach J
Mol Pain . 2024 Jan; 20:17448069241226553. PMID: 38172079
Ultraviolet B (UVB) radiation induces cutaneous inflammation, leading to thermal and mechanical hypersensitivity. Here, we examine the mechanical properties and profile of tactile and nociceptive peripheral afferents functionally disrupted by...
6.
Gutierrez S, Eisenach J, Boada M
Mol Pain . 2021 Jul; 17:17448069211024082. PMID: 34229504
Some types of cancer are commonly associated with intense pain even at the early stages of the disease. The mandible is particularly vulnerable to metastasis from breast cancer, and this...
7.
Salvo E, Campana W, Scheff N, Nguyen T, Jeong S, Wall I, et al.
Pain . 2020 Jul; 161(11):2592-2602. PMID: 32658150
Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with...
8.
Boada M, Ririe D, Martin C, Martin S, Kim S, Eisenach J, et al.
Pain . 2020 Feb; 161(5):960-969. PMID: 32040075
Pain alters cognitive performance through centrally mediated effects in the brain. In this study, we hypothesized that persistent activation of peripheral nociceptors after injury would lead to the development of...
9.
Boada M, Martin T, Parker R, Houle T, Eisenach J, Ririe D
Pain . 2020 Feb; 161(5):949-959. PMID: 32040074
Pain and hypersensitivity months after peripheral injury reflect abnormal input from peripheral afferents likely in conjunction with central sensitization. We hypothesize that peripheral changes occur in defined sensory afferents and...
10.
Gutierrez S, Alvarado-Vazquez P, Eisenach J, Romero-Sandoval E, Boada M
Mol Pain . 2019 Apr; 15:1744806919845750. PMID: 31012376
Since the failure of specific substance P antagonists to induce analgesia, the role of tachykinins in the development of neuropathic pain states has been discounted. This conclusion was reached without...