M Comb
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Explore the profile of M Comb including associated specialties, affiliations and a list of published articles.
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24
Citations
738
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Recent Articles
1.
Ouyang Y, Tan Y, Comb M, Liu C, Martone M, Siesjo B, et al.
J Cereb Blood Flow Metab
. 1999 Oct;
19(10):1126-35.
PMID: 10532637
Release of cytochrome c (cyt c) into cytoplasm initiates caspase-mediated apoptosis, whereas activation of Akt kinase by phosphorylation at serine-473 prevents apoptosis in several cell systems. To investigate cell death...
2.
Borsook D, Falkowski O, Rosen H, Comb M, Hyman S
J Neurosci
. 1994 Dec;
14(12):7261-71.
PMID: 7996174
Stressful stimuli strongly induce proenkephalin gene expression within the paraventricular nucleus (PVN) of the hypothalamus. A human proenkephalin-beta-galactosidase fusion gene has previously been shown to give correct phenotypic expression and...
3.
Borsook D, Konradi C, Falkowski O, Comb M, Hyman S
Mol Endocrinol
. 1994 Feb;
8(2):240-8.
PMID: 8170480
We have established a transgenic model to facilitate the study of stress-induced gene regulation in the hypothalamus. This model, which uses a human proenkephalin-beta-galactosidase fusion gene, readily permits anatomic and...
4.
Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, et al.
Mol Endocrinol
. 1994 Jan;
8(1):116-25.
PMID: 8152426
Transgenic mice expressing an Escherichia coli beta-galactosidase reporter gene under the control of 3 kilobases of human proenkephalin gene 5'-flanking sequence and 1.2 kilobases of 3'-flanking sequence exhibited an anatomically...
5.
Comb M, Hyman S, Kobierski L, Chu H, Van Nguyen T
NIDA Res Monogr
. 1991 Jan;
111:149-70.
PMID: 1663581
No abstract available.
6.
Van Nguyen T, Kobierski L, Comb M, Hyman S
J Neurosci
. 1990 Aug;
10(8):2825-33.
PMID: 2167356
Membrane depolarization is a critical component of neural signaling; in recent years there also has been a great deal of evidence that membrane depolarization can regulate neural gene expression. Therefore,...
7.
Comb M, Goodman H
Nucleic Acids Res
. 1990 Jul;
18(13):3975-82.
PMID: 1695733
DNA methylation at HpaII (CmCGG) sites inhibits expression of a human proenkephalin-CAT fusion gene when it is transiently expressed in CV-1 cells or stably expressed in C6-glioma cells. The inhibitory...
8.
Ross M, Evinger M, Hyman S, Carroll J, Mucke L, Comb M, et al.
J Neurosci
. 1990 Feb;
10(2):520-30.
PMID: 2303857
The rat gene encoding phenylethanolamine N-methyltransferase (PNMT) was cloned and a consensus sequence for a glucocorticoid response element (GRE) was found at -513 bp, 5' to the transcriptional start site....
9.
Hyman S, Comb M, Pearlberg J, Goodman H
Mol Cell Biol
. 1989 Jan;
9(1):321-4.
PMID: 2538722
An enhancer with two DNA elements, one containing the sequence CGTCA, is required for cyclic AMP- and phorbol ester-inducible transcription of the human proenkephalin gene. We report that an AP-2...
10.
Comb M, Mermod N, Hyman S, Pearlberg J, Ross M, Goodman H
EMBO J
. 1988 Dec;
7(12):3793-805.
PMID: 2850173
Synthesis of the endogenous opioid precursor, proenkephalin, is regulated by neurotransmitters and membrane depolarization. These events act through second messenger dependent signal transduction pathways via a short inducible DNA enhancer...