M C McGuinness
Overview
Explore the profile of M C McGuinness including associated specialties, affiliations and a list of published articles.
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19
Citations
312
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Recent Articles
1.
McGuinness M, Lu J, Zhang H, Dong G, Heinzer A, Watkins P, et al.
Mol Cell Biol
. 2003 Jan;
23(2):744-53.
PMID: 12509471
Peroxisomal disorders have been associated with malfunction of peroxisomal metabolic pathways, but the pathogenesis of these disorders is largely unknown. X-linked adrenoleukodystrophy (X-ALD) is associated with elevated levels of very-long-chain...
2.
McGuinness M, Zhang H, Smith K
Mol Genet Metab
. 2001 Oct;
74(1-2):256-63.
PMID: 11592822
X-linked adrenoleukodystrophy (X-ALD) is an inherited neurometabolic disorder associated with elevated levels of saturated unbranched very-long-chain fatty acids (VLCFA; C > 22:0) in plasma and tissues, and reduced VLCFA beta-oxidation...
3.
McGuinness M, Wei H, Smith K
Expert Opin Investig Drugs
. 2000 Nov;
9(9):1985-92.
PMID: 11060787
Clinically, peroxisome biogenesis disorders (PBDs) are a group of lethal diseases with a continuum of severity of clinical symptoms ranging from the most severe form, Zellweger syndrome, to the milder...
4.
Wei H, Kemp S, McGuinness M, Moser A, Smith K
Ann Neurol
. 2000 Mar;
47(3):286-96.
PMID: 10716247
Inherited aberrant peroxisome assembly results in a group of neurological diseases termed peroxisome biogenesis disorders (PBDs). PBDs include three major clinical phenotypes that represent a continuum of clinical features from...
5.
McGuinness M, Smith K
Arch Immunol Ther Exp (Warsz)
. 1999 Dec;
47(5):281-7.
PMID: 10604233
X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disease that affects approximately 1 in 25 000 males. It is characterized by elevated levels of saturated very long chain fatty acids (VLCFA),...
6.
Steinberg S, Wang S, McGuinness M, Watkins P
Mol Genet Metab
. 1999 Sep;
68(1):32-42.
PMID: 10479480
Activation of fatty acids, catalyzed by acyl-coenzyme A (acyl-CoA) synthetases, is required for their subsequent metabolism. Peroxisomes and microsomes contain very-long-chain acyl-CoA synthetases (VLCSs) capable of activating fatty acids with...
7.
Kemp S, Wei H, Lu J, Braiterman L, McGuinness M, Moser A, et al.
Nat Med
. 1998 Nov;
4(11):1261-8.
PMID: 9809549
As more functional redundancy in mammalian cells is discovered, enhanced expression of genes involved in alternative pathways may become an effective form of gene therapy. X-linked adrenoleukodystrophy (X-ALD) is a...
8.
Braiterman L, Zheng S, Watkins P, Geraghty M, Johnson G, McGuinness M, et al.
Hum Mol Genet
. 1998 Mar;
7(2):239-47.
PMID: 9425230
X-Linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disorder characterized by reduced peroxisomal very long chain fatty acid (VLCFA) beta-oxidation. The X - ALD gene product (ALDP) is a peroxisomal transmembrane protein...
9.
McGuinness M, Powers J, Bias W, Schmeckpeper B, Segal A, Gowda V, et al.
J Neuroimmunol
. 1997 May;
75(1-2):174-82.
PMID: 9143252
The two most common forms of X-linked adrenoleukodystrophy (X-ALD) are the cerebral forms (CER) with an inflammatory demyelinating reaction that resembles multiple sclerosis, and adrenomyeloneuropathy (AMN) which involves primarily the...
10.
Yang H, Adamo M, Koval A, McGuinness M, Yang Y, LeRoith D, et al.
Mol Endocrinol
. 1995 Oct;
9(10):1380-95.
PMID: 8544846
Rat insulin-like growth factor I (IGF-I) mRNAs contain multiple 5'-untranslated regions due to the use of leader exons transcribed from several transcription initiation sites and to alternative splicing within leader...