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M C Lans

Explore the profile of M C Lans including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 224
Followers 0
Related Specialties
Pharmacology
Toxicology
Biochemistry
Top 10 Co-Authors
A Brouwer
M J Saraiva
A J Murk
S Safe
M R Almeida
E Meussen
T J Visser
M Willemsen
C Spiertz
D C Morse
Published In
Eur J Pharmacol
Toxicol Ind Health
Chem Biol Interact
Toxicol In Vitro
Endocrine
Affiliations
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Recent Articles
1.
Use of monolayers of primary rat kidney cortex cells for nephrotoxicity studies
Bruggeman I, Mertens J, Temmink J, Lans M, Vos R, van Bladeren P
Toxicol In Vitro . 2010 Aug; 3(4):261-9. PMID: 20702291
Kidney cells were isolated from rat kidney cortex and maintained in short-term monolayer cultures. A number of important parameters were studied in order to establish the usefulness of these cells...
2.
Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health
Brouwer A, Morse D, Lans M, Schuur A, Murk A, Bergman A, et al.
Toxicol Ind Health . 1998 Feb; 14(1-2):59-84. PMID: 9460170
Several classes of environmental contaminants have been claimed or suggested to possess endocrine-disrupting potency, which may result in reproductive problems and developmental disorders. In this paper the focus is on...
3.
Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis
Almeida M, Damas A, Lans M, Brouwer A, Saraiva M
Endocrine . 1997 Jun; 6(3):309-15. PMID: 9368688
The majority of the known transthyretin (TTR) variants are associated with amyloidosis, but there are also variants associated with euthyroid hyperthyroxinemia and others are apparently nonpathogenic. TTR Met 119 is...
4.
Different competition of thyroxine binding to transthyretin and thyroxine-binding globulin by hydroxy-PCBs, PCDDs and PCDFs
Lans M, Spiertz C, Brouwer A, Koeman J
Eur J Pharmacol . 1994 Apr; 270(2-3):129-36. PMID: 8039542
In an earlier study several hydroxylated polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) competitively displaced [125I]thyroxine (T4) from transthyretin with different potencies. Transthyretin is the major T4 transport protein...
5.
Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin
Lans M, Willemsen M, Meussen E, Safe S, Brouwer A
Chem Biol Interact . 1993 Jul; 88(1):7-21. PMID: 8330325
Previous results from our laboratory indicated specific and competitive interactions of hydroxylated metabolites of 3,3', 4,4'-tetrachlorobiphenyl with the plasma thyroid hormone transport protein, transthyretin (TTR), in rats in vivo and...